CCL12

趋化因子（C-C基序）配体12
Chemokine (C-C motif) ligand 12
趋化因子（C-C基序）配体12; Chemokine (C-C motif) ligand 12
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 3IFD
标识
代号	Ccl12; MCP-5; Scya12
扩展标识	遗传学：158105 同源基因：2245 GeneCards: Ccl12 Gene
基因本体论描述
分子功能	· cytokine activity; · chemokine activity; · CCR2 chemokine receptor binding;
细胞成分	· extracellular region; · extracellular space;
生物过程	· angiogenesis; · monocyte chemotaxis; · chemotaxis; · inflammatory response; · immune response;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	20293
Ensembl	ENSMUSG00000035352
UniProt	Q62401
mRNA序列	NM_011331
蛋白序列	NP_035461
基因位置	Chr 11:; 82.1 – 82.1 Mb
PubMed查询	[1]
	查; 论; 编;

CCL12（英语：Chemokine (C-C motif) ligand 12）是一个小型的细胞因子，属于CC趋化因子家族，最早在鼠类中发现。它还被叫做单核细胞趋化蛋白5（英语：monocyte chemotactic protein 5，MCP-5），又由于其和人类趋化因子MCP-1的相似性，有时候也被称为MCP-1相关趋化因子（英语：MCP-1-related chemokine）。CCL12特异性影响嗜酸性粒细胞、单核细胞和淋巴细胞^[1]。这个趋化因子正常情况下存在于淋巴结和胸腺中，其表达能显著诱导巨噬细胞^[1]^[2]。编码CCL12的基因发现于小鼠染色体11上^[2]。

参考文献

^ ^1.0 ^1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.
^ ^2.0 ^2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.

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[jia-1] 1.0 ^1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.

[sarafi-2] 2.0 ^2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.

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