Windblight Ganon appears in Hyrule Warriors: Age of Calamity, filling roughly the same role it did in Breath of the Wild. Unlike its appearance in Breath of the Wild, it now bears a second, larger hand cannon replacing its left hand, and it now has four tubes of Malice connecting its arms to its back. It also sports purple glyphs, signifying its elemental affinity with wind, and has a red eye instead of a blue one.
Windblight Ganon first appears in the "Air and Lightning" Scenario after Calamity Ganon is revived. Windblight Ganon fights with Revali on top of Divine Beast Vah Medoh for the control of the Divine Beast. Before the fatal blow that should have killed Revali is fired, a portal opens, bringing the Rito warrior Teba from 100 years into the future. After Link, Zelda, and their allies have saved Urbosa from Thunderblight Ganon, they arrive on Divine Beast Vah Medoh to assist Revali and Teba, only for Windblight Ganon to retreat. It later reappears to try and stop both Rito warriors while they are destroying enemy camps with Divine Beast Vah Medoh, before it is finally vanquished.
Windblight Ganon, along with the other Blight Ganons, is later revived by Astor using the souls of a number of Yiga Footsoldiers. Astor then uses the Blight Ganons in the "Each Step Like Thunder" Scenario, aiding him in the Siege of Fort Hateno when trying to end the lives of both Link and Zelda. Windblight Ganon, along with the other Blight Ganons, overpower Link while he buys time for Zelda and Impa to escape, but Zelda ends up awakening her powers, temporarily stunning all the Blight Ganons. Windblight Ganon appears again in an attempt to stop the heroes from activating a device made by Purah.
Later, when the heroes lay siege to Hyrule Castle, Windblight Ganon is summoned one final time, along with the other Blight Ganons, to defend Hyrule Castle; however, it is defeated by the heroic forces.
