Pages that link to "Q39954178"
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The following pages link to Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. (Q39954178):
Displaying 30 items.
- In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor (Q24650264) (← links)
- Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking (Q27487538) (← links)
- Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target (Q27659903) (← links)
- Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding (Q27665956) (← links)
- Design and synthesis of potent macrocyclic renin inhibitors (Q27666087) (← links)
- Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C (Q28080225) (← links)
- Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase (Q28480947) (← links)
- Macrocyclic inhibitors of HCV NS3 protease (Q33475839) (← links)
- P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis (Q33969291) (← links)
- MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants (Q34276394) (← links)
- Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase (Q35139538) (← links)
- Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains. (Q35935502) (← links)
- Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system (Q36438628) (← links)
- Large-scale production and structural and biophysical characterizations of the human hepatitis B virus polymerase (Q37644005) (← links)
- The Journey to the Discovery of Boceprevir: An NS3–NS4 HCV Protease Inhibitor for the Treatment of Chronic Hepatitis C (Q37790484) (← links)
- TMC435 for the treatment of chronic hepatitis C. (Q38012160) (← links)
- Simeprevir for the treatment of chronic hepatitis C genotype 1 infection (Q38216582) (← links)
- Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing. (Q38788003) (← links)
- Process Chemistry in Antiviral Research (Q38997200) (← links)
- Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor (Q39159324) (← links)
- TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage (Q39329242) (← links)
- Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure (Q39507721) (← links)
- In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435. (Q39736457) (← links)
- LC-ESI-MS/MS analysis and pharmacokinetics of GP205, an innovative potent macrocyclic inhibitor of hepatitis C virus NS3/4A protease in rats (Q41255502) (← links)
- In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir (Q41595435) (← links)
- Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease (Q42822570) (← links)
- Outlook of the Antiviral Drug Era, Now More Than 50 Years after Description of the First Antiviral Drug (Q56786253) (← links)
- Tetrazoles via Multicomponent Reactions (Q61802827) (← links)
- Safety and efficacy of the combination simeprevir-sofosbuvir in HCV genotype 1- and 4-mono-infected patients from the French ANRS CO22 hepather cohort (Q64083501) (← links)
- A Versatile Protocol for the Synthesis of Pyrazolyl-Substituted Pyridinium and Guanidinium Salts from Pyridone and Urea Derivatives (Q64169355) (← links)