Pages that link to "Q34477195"
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The following pages link to Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. (Q34477195):
Displaying 50 items.
- Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease? (Q21202832) (← links)
- Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors (Q24296622) (← links)
- OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD (Q24312778) (← links)
- Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis (Q24316177) (← links)
- Protein folding: then and now (Q24671711) (← links)
- Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis (Q26764754) (← links)
- Protein Folding and Mechanisms of Proteostasis (Q26801512) (← links)
- Assessing the causes and consequences of co-polymerization in amyloid formation (Q26824195) (← links)
- Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions (Q27003966) (← links)
- Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis (Q27004511) (← links)
- Amyloid diseases of the heart: current and future therapies (Q27023836) (← links)
- Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins (Q27649069) (← links)
- Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies † (Q27652272) (← links)
- Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors (Q27653350) (← links)
- Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies † (Q27653642) (← links)
- Amyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSES (Q27656412) (← links)
- Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis (Q27656578) (← links)
- A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity (Q27658823) (← links)
- Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma (Q27659009) (← links)
- Trapping of palindromic ligands within native transthyretin prevents amyloid formation (Q27665687) (← links)
- Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity (Q27671971) (← links)
- Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate (Q27675997) (← links)
- AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin (Q27678369) (← links)
- Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade (Q27679360) (← links)
- Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors (Q27679824) (← links)
- Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn (Q27680199) (← links)
- Structural evidence for asymmetric ligand binding to transthyretin (Q27701741) (← links)
- Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses (Q27711326) (← links)
- Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms (Q28286324) (← links)
- Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial (Q28304712) (← links)
- Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein (Q28731292) (← links)
- Clinical and biomarker changes in dominantly inherited Alzheimer's disease (Q29619940) (← links)
- Cell and molecular biology of transthyretin and thyroid hormones. (Q30360169) (← links)
- In Silico Carborane Docking to Proteins and Potential Drug Targets (Q30405058) (← links)
- Molecules that target beta-amyloid (Q33303421) (← links)
- The threat of instability: neurodegeneration predicted by protein destabilization and aggregation propensity (Q33356208) (← links)
- Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis (Q33423160) (← links)
- Identifying protein stabilizing ligands using GroEL. (Q33508608) (← links)
- Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones (Q33869299) (← links)
- Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses (Q34096983) (← links)
- A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate (Q34300151) (← links)
- Quantification of quaternary structure stability in aggregation-prone proteins under physiological conditions: the transthyretin case. (Q34379670) (← links)
- Recent progress in the understanding and treatment of transthyretin amyloidosis (Q34416193) (← links)
- The amyloid state and its association with protein misfolding diseases. (Q34421102) (← links)
- An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis (Q34428314) (← links)
- Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion (Q34561167) (← links)
- A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin (Q34576022) (← links)
- Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis (Q34581917) (← links)
- Amyloid formation by globular proteins under native conditions (Q34905853) (← links)
- Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures (Q34911325) (← links)