Pages that link to "Q28264162"
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The following pages link to Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein (Q28264162):
Displaying 50 items.
- The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury (Q24601910) (← links)
- THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE (Q26740104) (← links)
- Lysosomal cathepsins and their regulation in aging and neurodegeneration (Q26749121) (← links)
- Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors (Q26771736) (← links)
- Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate (Q26782938) (← links)
- Inflammasomes: mechanism of action, role in disease, and therapeutics (Q27001186) (← links)
- Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic (Q28235248) (← links)
- The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity (Q28238581) (← links)
- Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein (Q28247574) (← links)
- Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence (Q28259920) (← links)
- Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function (Q28276622) (← links)
- The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases (Q28482305) (← links)
- The NALP3 inflammasome is involved in the innate immune response to amyloid-beta (Q29615595) (← links)
- Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases (Q30319326) (← links)
- Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease (Q30490690) (← links)
- Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex (Q33412456) (← links)
- The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L. (Q33508911) (← links)
- QSAR models for predicting cathepsin B inhibition by small molecules--continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules (Q33535606) (← links)
- Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases (Q33861680) (← links)
- An overview of APP processing enzymes and products (Q33927819) (← links)
- Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors (Q33974696) (← links)
- Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion (Q34076284) (← links)
- Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process (Q34110227) (← links)
- Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis (Q34302241) (← links)
- Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication (Q34376138) (← links)
- Inflammasomes as therapeutic targets for Alzheimer's disease (Q34547897) (← links)
- Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. (Q34656871) (← links)
- Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology (Q35171676) (← links)
- Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease (Q35596997) (← links)
- A missense variant in CST3 exerts a recessive effect on susceptibility to age-related macular degeneration resembling its association with Alzheimer's disease. (Q35698081) (← links)
- Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. (Q36259524) (← links)
- Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease (Q36320154) (← links)
- Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration (Q36676838) (← links)
- Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease (Q36764094) (← links)
- Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease (Q37124928) (← links)
- Gene therapy in Alzheimer's disease - potential for disease modification (Q37295252) (← links)
- Cell biology, regulation and inhibition of beta-secretase (BACE-1). (Q37416750) (← links)
- Apoptosis and in vitro Alzheimer disease neuronal models. (Q37513632) (← links)
- The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. (Q37598633) (← links)
- Alzheimer's disease and the amyloid-beta peptide (Q37671455) (← links)
- Autophagic/lysosomal dysfunction in Alzheimer's disease (Q37690932) (← links)
- Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease (Q37763948) (← links)
- Animal models of Alzheimer's disease: an understanding of pathology and therapeutic avenues (Q37771023) (← links)
- Biology and pathophysiology of the amyloid precursor protein (Q37869935) (← links)
- The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond (Q37987919) (← links)
- Protein truncation as a common denominator of human neurodegenerative foldopathies (Q38091670) (← links)
- Cysteine cathepsins in neurological disorders (Q38162775) (← links)
- On the Run for Hippocampal Plasticity (Q38403023) (← links)
- Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors (Q38409713) (← links)
- Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. (Q38780921) (← links)