Pages that link to "Q27682383"
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The following pages link to Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B (Q27682383):
Displaying 50 items.
- DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome (Q26745413) (← links)
- A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity (Q27680722) (← links)
- Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6 (Q27682291) (← links)
- The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine (Q27700733) (← links)
- Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors (Q28541616) (← links)
- Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors (Q28546672) (← links)
- Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening (Q30396689) (← links)
- An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3 (Q33688195) (← links)
- Bioactive marine drugs and marine biomaterials for brain diseases (Q33736687) (← links)
- CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells (Q33864755) (← links)
- The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation (Q33952905) (← links)
- Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitors (Q34621349) (← links)
- Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. (Q35283950) (← links)
- Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I. (Q35288200) (← links)
- Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme. (Q35380915) (← links)
- Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. (Q35618794) (← links)
- A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication (Q36402679) (← links)
- Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress (Q37621110) (← links)
- Recent progress in neuroactive marine natural products (Q37639029) (← links)
- Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms (Q38263124) (← links)
- DYRK1A inhibition as potential treatment for Alzheimer's disease. (Q38807264) (← links)
- Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease (Q38850493) (← links)
- Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases. (Q38852014) (← links)
- cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease. (Q39040344) (← links)
- Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. (Q41508786) (← links)
- 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. (Q42353177) (← links)
- A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. (Q42702995) (← links)
- Predicting targets of compounds against neurological diseases using cheminformatic methodology. (Q44608034) (← links)
- Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer's Disease Therapeutic Agents (Q46251798) (← links)
- A Challenging Pie to Splice: Drugging the Spliceosome. (Q46298922) (← links)
- Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases. (Q47250488) (← links)
- In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome (Q47319838) (← links)
- Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design. (Q47703266) (← links)
- Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents. (Q47884524) (← links)
- Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature (Q48001145) (← links)
- DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives (Q49632429) (← links)
- Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions. (Q50264747) (← links)
- Synthesis of 2-Aminoimidazolones and Imidazolones by (3 2) Annulation of Azaoxyallyl Cations. (Q52721899) (← links)
- New 5-ylidene rhodanine derivatives based on the dispacamide A model. (Q54374029) (← links)
- Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma. (Q55447462) (← links)
- Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer's Disease: A Computational Study (Q58557345) (← links)
- Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies (Q58696298) (← links)
- Identification of Plant Homologues of Dual Specificity Yak1-Related Kinases (Q59052323) (← links)
- Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A (Q59127645) (← links)
- Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice (Q64078334) (← links)
- The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair (Q64091236) (← links)
- Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation (Q64107328) (← links)
- Solvolysis Artifacts: Leucettazoles as Cryptic Macrocyclic Alkaloid Dimers from a Southern Australian Marine Sponge, sp (Q64251375) (← links)
- Predicting Blood⁻Brain Barrier Permeability of Marine-Derived Kinase Inhibitors Using Ensemble Classifiers Reveals Potential Hits for Neurodegenerative Disorders (Q64251797) (← links)
- Advances in drug discovery for human beta cell regeneration (Q88709323) (← links)