Pages that link to "Q27643305"
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The following pages link to Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs (Q27643305):
Displaying 50 items.
- IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis (Q24300707) (← links)
- Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis (Q24609324) (← links)
- (Q27640761) (redirect page) (← links)
- Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein † ‡ (Q27651733) (← links)
- Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) † (Q27652682) (← links)
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands (Q27657282) (← links)
- Recognition of Smac-mimetic compounds by the BIR domain of cIAP1 (Q27665119) (← links)
- Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination (Q27675192) (← links)
- Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) (Q27678027) (← links)
- The structure of XIAP BIR2: understanding the selectivity of the BIR domains (Q27679855) (← links)
- Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor (Q27680601) (← links)
- Small molecules destabilize cIAP1 by activating auto-ubiquitylation (Q28266432) (← links)
- Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP (Q28283505) (← links)
- The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer (Q28468300) (← links)
- Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists (Q28481449) (← links)
- Reaching for high-hanging fruit in drug discovery at protein-protein interfaces (Q29547258) (← links)
- A specificity map for the PDZ domain family (Q33373127) (← links)
- Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. (Q33502518) (← links)
- Isolation of peptides blocking the function of anti-apoptotic Livin protein (Q33533589) (← links)
- Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer (Q33589984) (← links)
- Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134. (Q33849311) (← links)
- Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins (Q34116053) (← links)
- SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner (Q34229779) (← links)
- Cyclopeptide Smac mimetics as antagonists of IAP proteins (Q34382271) (← links)
- Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells (Q34512395) (← links)
- Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. (Q35024837) (← links)
- Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. (Q35032216) (← links)
- Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. (Q35072876) (← links)
- X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma (Q35078238) (← links)
- Synthetic mimetics of protein secondary structure domains (Q35688001) (← links)
- Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL. (Q36056007) (← links)
- Using protein motion to read, write, and erase ubiquitin signals (Q36283663) (← links)
- Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon (Q36559689) (← links)
- Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP (Q36909606) (← links)
- Inhibitor of apoptosis proteins as targets for anticancer therapy (Q36950485) (← links)
- Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation (Q36954601) (← links)
- Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases (Q37143013) (← links)
- Design of small-molecule peptidic and nonpeptidic Smac mimetics (Q37176751) (← links)
- Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases (Q37185121) (← links)
- IAP proteins as targets for drug development in oncology (Q37209606) (← links)
- A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice (Q37249659) (← links)
- Inhibitor of apoptosis proteins in hematological malignancies (Q37336610) (← links)
- Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts (Q37340219) (← links)
- Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction. (Q37412834) (← links)
- SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. (Q37445045) (← links)
- X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists (Q37454149) (← links)
- Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic (Q37457562) (← links)
- Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases (Q37481457) (← links)
- Small molecules and targeted therapies in distant metastatic disease. (Q37555793) (← links)
- cIAP2 as a therapeutic target in colorectal cancer and other malignancies. (Q37605889) (← links)