Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/Smad/ERK signaling pathway (Q99579045)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32952652 AND SRC:MED&resulttype=core&format=json

24 September 2020

title

Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/Smad/ERK signaling pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32952652 AND SRC:MED&resulttype=core&format=json

24 September 2020

1 reference

Yan-Lu Liu

1

1 reference

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24 September 2020

Bao-Yi Chen

2

1 reference

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24 September 2020

Juan Nie

3

1 reference

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24 September 2020

Guang-Hui Zhao

4

1 reference

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24 September 2020

Jian-Yi Zhuo

5

1 reference

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24 September 2020

Jie Yuan

6

1 reference

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24 September 2020

Yu-Cui Li

7

1 reference

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24 September 2020

Ling-Li Wang

8

1 reference

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24 September 2020

Zhi-Wei Chen

9

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24 September 2020

publication date

4 September 2020

1 reference

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Experimental and Therapeutic Medicine

24 September 2020

published in

1 reference

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24 September 2020

volume

20

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24 September 2020

issue

5

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24 September 2020

page(s)

62

1 reference

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Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice

24 September 2020

cites work

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Aryl hydrocarbon receptor, a tumor grade‑associated marker of oral cancer, is directly downregulated by polydatin: A pilot study

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Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells

10 February 2021

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SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice.

10 February 2021

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10 February 2021

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Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism

10 February 2021

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Protective effect of hydroxysafflor yellow A on bleomycin- induced pulmonary inflammation and fibrosis in rats

10 February 2021

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Role of resveratrol in regulation of cellular defense systems against oxidative stress.

10 February 2021

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Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway

10 February 2021

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HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway

10 February 2021

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[Polydatin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling pathway]

10 February 2021

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Resveratrol and polydatin as modulators of Ca(2 ) mobilization in the cardiovascular system

10 February 2021

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Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition

10 February 2021

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Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways.

10 February 2021

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Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants

10 February 2021

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Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.

10 February 2021

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Polydatin protects the respiratory system from PM2.5 exposure

10 February 2021

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Modulatory potential of resveratrol during lung inflammatory disease

10 February 2021

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HSP27 regulates TGF-β mediated lung fibroblast differentiation through the Smad3 and ERK pathways

10 February 2021

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Inhibitory Effects of Astragaloside IV on Bleomycin-Induced Pulmonary Fibrosis in Rats Via Attenuation of Oxidative Stress and Inflammation

10 February 2021

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Obaculactone protects against bleomycin-induced pulmonary fibrosis in mice

10 February 2021

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Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-κB pathway

10 February 2021

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Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin-induced pulmonary fibrosis in mice

10 February 2021

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Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?

10 February 2021

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Inflammatory response mechanisms exacerbating hypoxemia in coexistent pulmonary fibrosis and sleep apnea

10 February 2021

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Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury

10 February 2021

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The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis

10 February 2021

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Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells

10 February 2021

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Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.

10 February 2021

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The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation

10 February 2021

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NF-κB RNAi decreases the Bax/Bcl-2 ratio and inhibits TNF-α-induced apoptosis in human alveolar epithelial cells

10 February 2021

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EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation

10 February 2021

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Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling

10 February 2021

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The big clinical trials in idiopathic pulmonary fibrosis

10 February 2021

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Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis.

10 February 2021

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Polydatin up-regulates clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro

10 February 2021

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Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.

10 February 2021

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ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion.

10 February 2021

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Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells

10 February 2021

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Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats

10 February 2021

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10 February 2021

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Protective effect of polydatin against ischemia/reperfusion injury in rat heart.

10 February 2021

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The Medical Research Council chronic dyspnea score predicts the survival of patients with idiopathic pulmonary fibrosis

10 February 2021

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10 February 2021

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Differentiation plasticity regulated by TGF-beta family proteins in development and disease

10 February 2021

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Mining of biomarker genes from expressed sequence tags and differential display reverse transcriptase-polymerase chain reaction in the self-fertilizing fish, Kryptolebias marmoratus and their expression patterns in response to exposure to an endocri

10 February 2021

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Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats

10 February 2021

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ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells.

10 February 2021

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Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.

10 February 2021

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Specificity and versatility in tgf-beta signaling through Smads

10 February 2021

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Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.

10 February 2021

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Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

10 February 2021

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TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression

10 February 2021

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Feitai attenuates bleomycin-induced pulmonary fibrosis in rats

10 February 2021

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

10 February 2021

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Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol

10 February 2021

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Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease

10 February 2021

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Idiopathic pulmonary fibrosis: new insights in its pathogenesis

10 February 2021

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

10 February 2021

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

10 February 2021

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Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

10 February 2021

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Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation

10 February 2021

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TGFbeta signaling in growth control, cancer, and heritable disorders

10 February 2021

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Myeloperoxidase and protein oxidation in cystic fibrosis

10 February 2021

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10 February 2021

TGF-beta and fibrosis

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

10 February 2021

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Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

10 February 2021

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Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

10 February 2021

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Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A

10 February 2021

1 reference

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The role of TGF-beta in pulmonary fibrosis

10 February 2021

1 reference

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Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse

10 February 2021

1 reference

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10 February 2021

Identifiers

DOI

10.3892/ETM.2020.9190

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32952652 AND SRC:MED&resulttype=core&format=json

24 September 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32952652 AND SRC:MED&resulttype=core&format=json

24 September 2020

PubMed publication ID

32952652

1 reference