Metabolic underpinnings of leukemia pathology and treatment (Q98154686)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32721091 AND SRC:MED&resulttype=core&format=json

9 August 2020

title

Metabolic underpinnings of leukemia pathology and treatment (English)

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9 August 2020

3

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9 August 2020

author name string

Travis Nemkov

series ordinal

1

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9 August 2020

Angelo D'Alessandro

series ordinal

2

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9 August 2020

publication date

7 October 2018

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9 August 2020

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9 August 2020

volume

2

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9 August 2020

issue

2

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9 August 2020

page(s)

e1139

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Metabolomics – the link between genotypes and phenotypes

9 August 2020

cites work

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7 January 2021

Metabolomics: beyond biomarkers and towards mechanisms

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7 January 2021

Innovation: Metabolomics: the apogee of the omics trilogy

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7 January 2021

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells

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7 January 2021

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

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7 January 2021

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

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7 January 2021

The hematopoietic stem cell diet.

1 reference

7 January 2021

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.

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7 January 2021

Inflammation: a key regulator of hematopoietic stem cell fate in health and disease

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7 January 2021

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

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7 January 2021

Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions

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7 January 2021

Oxidative stress and hypoxia in normal and leukemic stem cells

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7 January 2021

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

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7 January 2021

The leukemic stem cell

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7 January 2021

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

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7 January 2021

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

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7 January 2021

The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells

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7 January 2021

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia

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7 January 2021

Metabolic plasticity in CLL: adaptation to the hypoxic niche

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7 January 2021

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

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7 January 2021

mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia

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7 January 2021

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling

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7 January 2021

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

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7 January 2021

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

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7 January 2021

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

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7 January 2021

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

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7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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7 January 2021

Molecular pathways: BCR-ABL.

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7 January 2021

Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells

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7 January 2021

Tyrosine Kinase Inhibitor Treatment for Newly Diagnosed Chronic Myeloid Leukemia

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7 January 2021

Ponatinib as second-line treatment in chronic phase chronic myeloid leukemia patients in real-life practice.

1 reference

7 January 2021

Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.

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7 January 2021

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

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7 January 2021

Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells.

1 reference

7 January 2021

Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients

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7 January 2021

Metabolite Profiling of the Plasma and Leukocytes of Chronic Myeloid Leukemia Patients

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7 January 2021

Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer

1 reference

7 January 2021

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

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7 January 2021

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

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7 January 2021

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

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7 January 2021

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

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7 January 2021

Acute Myeloid Leukemia

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7 January 2021

New strategies for relapsed acute myeloid leukemia: fertile ground for translational research

1 reference

7 January 2021

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

1 reference

7 January 2021

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

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7 January 2021

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China

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7 January 2021

Serum metabonomics of acute leukemia using nuclear magnetic resonance spectroscopy.

1 reference

7 January 2021

The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features

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7 January 2021

Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients

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7 January 2021

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

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7 January 2021

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

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7 January 2021

Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine

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7 January 2021

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

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7 January 2021

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

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7 January 2021

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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7 January 2021

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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7 January 2021

Hypoxia Induces Production of L-2-Hydroxyglutarate.

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7 January 2021

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

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7 January 2021

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.

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7 January 2021

Metabolic consequences of oncogenic IDH mutations

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7 January 2021

Oncometabolites: Unconventional triggers of oncogenic signalling cascades

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7 January 2021

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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7 January 2021

IDH mutation impairs histone demethylation and results in a block to cell differentiation

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7 January 2021

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

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7 January 2021

Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia

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7 January 2021

A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value.

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7 January 2021

High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.

1 reference

7 January 2021

A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways

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7 January 2021

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations

1 reference

7 January 2021

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

1 reference

7 January 2021

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

1 reference

7 January 2021

Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.

1 reference

7 January 2021

Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells

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7 January 2021

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

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7 January 2021

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

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7 January 2021

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

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7 January 2021

Therapeutic targeting of acute myeloid leukemia stem cells

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7 January 2021

Acute lymphoblastic leukemia

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7 January 2021

A revised definition for cure of childhood acute lymphoblastic leukemia.

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7 January 2021

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolid

1 reference

7 January 2021

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study

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7 January 2021

Genetic Basis of Acute Lymphoblastic Leukemia

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7 January 2021

Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in older adults: Current treatment and novel therapies

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7 January 2021

Emerging role of immunotherapy in precursor B-cell acute lymphoblastic leukemia

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7 January 2021

Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia

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7 January 2021

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

1 reference

7 January 2021

T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies

1 reference

7 January 2021

l-Asparaginase resistance in human leukemia—Asparagine synthetase

1 reference

7 January 2021

Catalyzing improvements in ALL therapy with asparaginase

1 reference

7 January 2021

Identification of Risk Factors in High-Dose Methotrexate-Induced Acute Kidney Injury in Childhood Acute Lymphoblastic Leukemia

1 reference

7 January 2021

Chemotherapy Pharmacodynamics and Neuroimaging and Neurocognitive Outcomes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

1 reference

7 January 2021

Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis

1 reference

7 January 2021

Histidine catabolism is a major determinant of methotrexate sensitivity

1 reference

7 January 2021

mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph and Ph-like B-ALL.

1 reference

7 January 2021

Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

1 reference

7 January 2021

Shift in energy metabolism caused by glucocorticoids enhances the effect of cytotoxic anti-cancer drugs against acute lymphoblastic leukemia cells

1 reference

7 January 2021

Metabolic gatekeeper function of B-lymphoid transcription factors

1 reference

7 January 2021

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

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7 January 2021

MYC and metabolism on the path to cancer

1 reference

7 January 2021

Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas

1 reference

7 January 2021

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

7 January 2021

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

1 reference

7 January 2021

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

1 reference

7 January 2021

Fine-Tuning of CD8( ) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

1 reference

7 January 2021

HPRT1 activity loss is associated with resistance to thiopurine in ALL.

1 reference

7 January 2021

Leukemia Stem Cells Microenvironment

1 reference

7 January 2021

A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms

1 reference

7 January 2021

Hypoxia regulates proliferation of acute myeloid leukemia and sensitivity against chemotherapy

1 reference

7 January 2021

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

1 reference

7 January 2021

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

1 reference

7 January 2021

Adipocytes impair leukemia treatment in mice

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7 January 2021

Cancer metabolism: fatty acid oxidation in the limelight

1 reference

7 January 2021

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.

1 reference

7 January 2021

Metabolomics of the tumor microenvironment in pediatric acute lymphoblastic leukemia

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7 January 2021

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

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7 January 2021

Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

1 reference

7 January 2021

AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth

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7 January 2021

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.

1 reference

7 January 2021

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.

1 reference

7 January 2021

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

1 reference

7 January 2021

Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment

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7 January 2021

Extracellular matrix: a dynamic microenvironment for stem cell niche

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7 January 2021

Mechanosignaling in bone health, trauma and inflammation.

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7 January 2021

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

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7 January 2021

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

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7 January 2021

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.

1 reference

7 January 2021

Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma

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7 January 2021

Role of YAP/TAZ in mechanotransduction

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7 January 2021

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways.

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7 January 2021

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene-induced senescence.

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7 January 2021

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

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7 January 2021

Tumour microenvironment: Destroying leukaemia stem cell habitats.

1 reference

7 January 2021

Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering

1 reference

7 January 2021

Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization.

1 reference

7 January 2021

Identifiers

DOI

10.1002/CNR2.1139

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32721091 AND SRC:MED&resulttype=core&format=json

9 August 2020

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