Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice (Q92605430)

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scientific article published on 13 January 2020

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English	Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice	scientific article published on 13 January 2020

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30 April 2020

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice (English)

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30 April 2020

Cynthia A Lemere

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30 April 2020

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Helen Crehan

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30 April 2020

Bin Liu

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30 April 2020

Martin Kleinschmidt

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30 April 2020

Jens-Ulrich Rahfeld

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30 April 2020

Kevin X Le

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30 April 2020

Barbara J Caldarone

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30 April 2020

Jeffrey L Frost

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30 April 2020

Thore Hettmann

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30 April 2020

Birgit Hutter-Paier

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30 April 2020

Brian O'Nuallain

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30 April 2020

Mi-Ae Park

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30 April 2020

Marcelo F DiCarli

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30 April 2020

Inge Lues

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30 April 2020

Stephan Schilling

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30 April 2020

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13 January 2020

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30 April 2020

Alzheimers Research & Therapy

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30 April 2020

12

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30 April 2020

1

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30 April 2020

12

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30 April 2020

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.

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Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.

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In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.

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An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

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Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores

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Pyroglutamylated amyloid-β peptide reverses cross β-sheets by a prion-like mechanism.

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IgG-effector functions: "the good, the bad and the ugly".

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Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

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MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice

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A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

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TREM2 Variants in Alzheimer's Disease

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

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Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

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11 February 2021

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

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11 February 2021

Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study

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[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).

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Chronological Age Impacts Immunotherapy and Monocyte Uptake Independent of Amyloid Load

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Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

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11 February 2021

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

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11 February 2021

A single ascending dose study of bapineuzumab in patients with Alzheimer disease

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11 February 2021

Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

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Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

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Cerebral hemorrhage after passive anti-Abeta immunotherapy

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IgG Fc receptors

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11 February 2021

Identifiers

10.1186/S13195-019-0579-8

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Europe PubMed Central

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30 April 2020

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Europe PubMed Central

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30 April 2020

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30 April 2020

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