Clinical trial of a humanized anti-IL-2/IL-15 receptor β chain in HAM/TSP (Q92554749)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31402625 AND SRC:MED&resulttype=core&format=json

30 April 2020

title

Clinical trial of a humanized anti-IL-2/IL-15 receptor β chain in HAM/TSP (English)

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30 April 2020

11

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10

Thomas A Waldmann

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30 April 2020

author name string

Yoshimi Enose-Akahata

1

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30 April 2020

Unsong Oh

2

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30 April 2020

Joan Ohayon

3

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30 April 2020

Bridgette Jeanne Billioux

4

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30 April 2020

Raya Massoud

5

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30 April 2020

Bonita R Bryant

6

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30 April 2020

Ashley Vellucci

7

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30 April 2020

Nyater Ngouth

8

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30 April 2020

Irene Cortese

9

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30 April 2020

publication date

5 July 2019

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Annals of clinical and translational neurology

30 April 2020

published in

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30 April 2020

volume

6

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30 April 2020

issue

8

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30 April 2020

page(s)

1383-1394

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Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy

30 April 2020

cites work

1 reference

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T memory stem cells in health and disease.

11 February 2021

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IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

11 February 2021

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Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

11 February 2021

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Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8 Memory Stem Cells in Acquired Aplastic Anemia.

11 February 2021

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T memory stem cells are the hierarchical apex of adult T-cell leukemia.

11 February 2021

1 reference

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Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

11 February 2021

1 reference

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HTLV-1 induces a Th1-like state in CD4 CCR4 T cells

11 February 2021

1 reference

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Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations

11 February 2021

1 reference

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Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

11 February 2021

1 reference

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Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia

11 February 2021

1 reference

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IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

11 February 2021

1 reference

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A human memory T cell subset with stem cell-like properties

11 February 2021

1 reference

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Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Reduced Tim-3 Expression on Human T-lymphotropic Virus Type I (HTLV-I) Tax-specific Cytotoxic T Lymphocytes in HTLV-I Infection

11 February 2021

1 reference

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Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease

11 February 2021

1 reference

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High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Abnormally high levels of virus-infected IFN-gamma CCR4 CD4 CD25 T cells in a retrovirus-associated neuroinflammatory disorder

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy

11 February 2021

1 reference

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Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Virus-induced dysfunction of CD4 CD25 T cells in patients with HTLV-I-associated neuroimmunological disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4 CD25 T Cells detected by peptide-specific, major histocompatibility complex-restricted antibodies i

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8 T cells in cerebrospinal fluid from patients with HAM/TSP.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8 cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Histopathological analysis of four autopsy cases of HTLV-I-associated myelopathy/tropical spastic paraparesis: inflammatory changes occur simultaneously in the entire central nervous system

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

HTLV-I associated myelopathy, a new clinical entity.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

Circulating CD8 cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6689682

11 February 2021

Identifiers

DOI

10.1002/ACN3.50820

1 reference

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30 April 2020

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30 April 2020

PubMed publication ID

31402625

1 reference