Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors (Q91776939)

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24 April 2020

title

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors (English)

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24 April 2020

5

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24 April 2020

Michael A McDonough

6

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24 April 2020

Rasheduzzaman Chowdhury

7

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24 April 2020

Christopher J. Schofield

8

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24 April 2020

1

James P Holt-Martyn

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24 April 2020

4

Kerstin Lippl

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24 April 2020

2

Anthony Tumber

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24 April 2020

author name string

Mohammed Z Rahman

3

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24 April 2020

publication date

1 March 2019

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24 April 2020

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volume

10

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issue

4

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24 April 2020

page(s)

500-504

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Creative Commons Attribution 3.0 Unported

24 April 2020

copyright license

start time

1 March 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

1 reference

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Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.

23 February 2021

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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

23 February 2021

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Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.

23 February 2021

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Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

23 February 2021

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HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

23 February 2021

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Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors

23 February 2021

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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

23 February 2021

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1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

23 February 2021

1 reference

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Inhibition of 2-oxoglutarate dependent oxygenases

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

23 February 2021

1 reference

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

23 February 2021

1 reference

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Hypoxia signalling in cancer and approaches to enforce tumour regression

23 February 2021

1 reference

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Selective inhibition of factor inhibiting hypoxia-inducible factor

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

Oxygen sensing by HIF hydroxylases

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

HIF-1 and mechanisms of hypoxia sensing

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6482412

23 February 2021

Identifiers

DOI

10.1039/C8MD00548F

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31057728 AND SRC:MED&resulttype=core&format=json

24 April 2020

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24 April 2020

PubMed publication ID

31057728

1 reference