Kinome expression profiling to target new therapeutic avenues in multiple myeloma (Q91753666)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31289205 AND SRC:MED&resulttype=core&format=json

24 April 2020

title

Kinome expression profiling to target new therapeutic avenues in multiple myeloma (English)

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11

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Jerome Moreaux

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author name string

Hugues de Boussac

1

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Angélique Bruyer

2

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Michel Jourdan

3

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Anke Maes

4

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Nicolas Robert

5

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Claire Gourzones

6

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Laure Vincent

7

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Anja Seckinger

8

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Guillaume Cartron

9

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Dirk Hose

10

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Alboukadel Kassambara

12

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Philippe Pasero

13

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24 April 2020

publication date

9 July 2019

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volume

105

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issue

3

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24 April 2020

page(s)

784-795

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Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance

24 April 2020

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Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma

23 February 2021

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The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms

23 February 2021

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Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

23 February 2021

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23 February 2021

The many faces of SRPK1

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Mps1/TTK: a novel target and biomarker for cancer

23 February 2021

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Kinase inhibitors as potential agents in the treatment of multiple myeloma

23 February 2021

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Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells.

23 February 2021

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OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases

23 February 2021

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The kinome 'at large' in cancer

23 February 2021

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MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

23 February 2021

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Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment

23 February 2021

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BUB1B promotes multiple myeloma cell proliferation through CDC20/CCNB axis

23 February 2021

1 reference

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GenomicScape: an easy-to-use web tool for gene expression data analysis. Application to investigate the molecular events in the differentiation of B cells into plasma cells

23 February 2021

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Enhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex

23 February 2021

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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

23 February 2021

1 reference

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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

23 February 2021

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International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation

23 February 2021

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Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

23 February 2021

1 reference

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NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers

23 February 2021

1 reference

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Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors

23 February 2021

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The Chk1 inhibitor AZD7762 sensitises p53 mutant breast cancer cells to radiation in vitro and in vivo.

23 February 2021

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The checkpoint kinase inhibitor AZD7762 potentiates chemotherapy-induced apoptosis of p53-mutated multiple myeloma cells

23 February 2021

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Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.

23 February 2021

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23 February 2021

Cancer statistics, 2012

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Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

23 February 2021

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Kinome expression profiling and prognosis of basal breast cancers

23 February 2021

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Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma

23 February 2021

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Chk1 suppressed cell death

23 February 2021

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Superior results of Total Therapy 3 (2003-33) in gene expression profiling-defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenance

23 February 2021

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Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.

23 February 2021

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Drug design with Cdc7 kinase: a potential novel cancer therapy target

23 February 2021

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Deletions of CDKN2C in multiple myeloma: biological and clinical implications

23 February 2021

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

23 February 2021

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Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation

23 February 2021

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Prediction of Survival in Multiple Myeloma Based on Gene Expression Profiles Reveals Cell Cycle and Chromosomal Instability Signatures in High-Risk Patients and Hyperdiploid Signatures in Low-Risk Patients: A Study of the Intergroupe Francophone du M

23 February 2021

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Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response

23 February 2021

1 reference

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The molecular classification of multiple myeloma

23 February 2021

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Total therapy 2 without thalidomide in comparison with total therapy 1: role of intensified induction and posttransplantation consolidation therapies

23 February 2021

1 reference

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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma

23 February 2021

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

23 February 2021

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Human claspin is required for replication checkpoint control

23 February 2021

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

A high bone marrow plasma cell labeling index in stable plateau-phase multiple myeloma is a marker for early disease progression and death.

23 February 2021

1 reference

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

23 February 2021

1 reference

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Cluster analysis and display of genome-wide expression patterns

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7049359

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

23 February 2021

1 reference

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10.3324/HAEMATOL.2018.208306

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31289205 AND SRC:MED&resulttype=core&format=json

24 April 2020

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24 April 2020

PubMed publication ID

31289205

1 reference