A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes (Q91725525)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

title

A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes (English)

1 reference

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24 April 2020

author name string

Joshua D Eaton

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

Laura Francis

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

Lee Davidson

3

1 reference

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24 April 2020

Steven West

4

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24 April 2020

publication date

5 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

volume

34

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24 April 2020

issue

1-2

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24 April 2020

page(s)

132-145

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism

24 April 2020

cites work

1 reference

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Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay

23 February 2021

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SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

23 February 2021

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Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control

23 February 2021

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Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination

23 February 2021

1 reference

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Transcription Elongation Can Affect Genome 3D Structure

23 February 2021

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An end in sight? Xrn2 and transcriptional termination by RNA polymerase II

23 February 2021

1 reference

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A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II

23 February 2021

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Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

23 February 2021

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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

23 February 2021

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The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells.

23 February 2021

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Two distinct transcription termination modes dictated by promoters

23 February 2021

1 reference

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Marker-free coselection for CRISPR-driven genome editing in human cells

23 February 2021

1 reference

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Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes.

23 February 2021

1 reference

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Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

23 February 2021

1 reference

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Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.

23 February 2021

1 reference

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Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition.

23 February 2021

1 reference

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Widespread Inducible Transcription Downstream of Human Genes

23 February 2021

1 reference

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Poly(A) Signal-Dependent Transcription Termination Occurs through a Conformational Change Mechanism that Does Not Require Cleavage at the Poly(A) Site

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides

23 February 2021

1 reference

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Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs.

23 February 2021

1 reference

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Unraveling the mechanistic features of RNA polymerase II termination by the 5'-3' exoribonuclease Rat1

23 February 2021

1 reference

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4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

23 February 2021

1 reference

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The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

The RNA polymerase II carboxy-terminal domain (CTD) code

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

The PP1 binding code: a molecular-lego strategy that governs specificity

23 February 2021

1 reference

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Ending the message: poly(A) signals then and now

23 February 2021

1 reference

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U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

23 February 2021

1 reference

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Rates of in situ transcription and splicing in large human genes

23 February 2021

1 reference

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Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing.

23 February 2021

1 reference

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Molecular architecture of the human pre-mRNA 3' processing complex

23 February 2021

1 reference

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RNA exosome depletion reveals transcription upstream of active human promoters

23 February 2021

1 reference

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3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA

23 February 2021

1 reference

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The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

23 February 2021

1 reference

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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Pause sites promote transcriptional termination of mammalian RNA polymerase II

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo model

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Transitions in RNA polymerase II elongation complexes at the 3' ends of genes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

How RNA polymerase II terminates transcription in higher eukaryotes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

A 5'----3' exoribonuclease of human placental nuclei: purification and substrate specificity

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6938672

23 February 2021

Identifiers

DOI

10.1101/GAD.332833.119

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31805520 AND SRC:MED&resulttype=core&format=json

24 April 2020

PubMed publication ID

31805520

1 reference