Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease (Q91687496)

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scientific article published on 21 June 2019

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English	Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease	scientific article published on 21 June 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31281249 AND SRC:MED&resulttype=core&format=json

24 April 2020

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31281249 AND SRC:MED&resulttype=core&format=json

24 April 2020

Alzheimer's disease

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Marta Pérez-González

2

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24 April 2020

Ana García-Osta

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24 April 2020

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Mar Cuadrado-Tejedor

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24 April 2020

Cristina García-Muñoz

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24 April 2020

Damián Muruzabal

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24 April 2020

Carolina García-Barroso

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24 April 2020

Obdulia Rabal

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24 April 2020

Víctor Segura

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24 April 2020

Juan A Sánchez-Arias

8

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24 April 2020

Julen Oyarzabal

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24 April 2020

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21 June 2019

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24 April 2020

Frontiers in Aging Neuroscience

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24 April 2020

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24 April 2020

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24 April 2020

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Creative Commons Attribution 4.0 International

21 June 2019

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LIMMA

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22 June 2022

https://europepmc.org/article/PMC/6597953

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?

1 reference

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Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer's disease

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CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies

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HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease

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Alzheimer's disease drug development pipeline: 2018.

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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.

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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

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From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases

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The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease

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Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging

1 reference

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Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity

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Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease

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Clinical Toxicities of Histone Deacetylase Inhibitors

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23 February 2021

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

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A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

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Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

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Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.

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Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

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Identifiers

10.3389/FNAGI.2019.00149

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31281249 AND SRC:MED&resulttype=core&format=json

24 April 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31281249 AND SRC:MED&resulttype=core&format=json

24 April 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31281249 AND SRC:MED&resulttype=core&format=json

24 April 2020

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