A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (Q91031402)

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Mehdi Bouhaddou

1 reference

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Jiewei Xu

1 reference

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Kirsten Obernier

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Matthew J O'Meara

1 reference

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Danielle L Swaney

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Tia A Tummino

2 references

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Ruth Hüttenhain

2 references

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Robyn M Kaake

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Alicia L Richards

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27 May 2020

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Beril Tutuncuoglu

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27 May 2020

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Jyoti Batra

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Kelsey Haas

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Maya Modak

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Minkyu Kim

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Paige Haas

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Benjamin J Polacco

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27 May 2020

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Hannes Braberg

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27 May 2020

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Manon Eckhardt

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27 May 2020

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Margaret Soucheray

2 references

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27 May 2020

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Merve Cakir

2 references

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27 May 2020

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Michael J McGregor

2 references

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27 May 2020

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Qiongyu Li

2 references

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27 May 2020

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Zun Zar Chi Naing

2 references

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27 May 2020

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Yuan Zhou

2 references

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27 May 2020

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Ilsa T Kirby

2 references

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27 May 2020

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James E Melnyk

2 references

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27 May 2020

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John S Chorba

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27 May 2020

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Kevin Lou

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27 May 2020

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Shizhong A Dai

2 references

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27 May 2020

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Wenqi Shen

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Ying Shi

2 references

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Ziyang Zhang

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12 June 2020

Inigo Barrio-Hernandez

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Inigo Barrio-Hernandez

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27 May 2020

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Danish Memon

2 references

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27 May 2020

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12 June 2020

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Claudia Hernandez-Armenta

2 references

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Tina Perica

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Kala B Pilla

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Sai J Ganesan

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Daniel J Saltzberg

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Rakesh Ramachandran

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Sara B Rosenthal

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Lorenzo Calviello

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Srivats Venkataramanan

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Srivats Venkataramanan

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Yizhu Lin

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Stephanie A Wankowicz

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Stephanie A Wankowicz

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Markus Bohn

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Raphael Trenker

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Janet M Young

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Devin Cavero

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Joe Hiatt

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Theo Roth

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Ujjwal Rathore

2 references

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Advait Subramanian

2 references

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Kris M White

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Lisa Miorin

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David Agard

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Michael Emerman

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Davide Ruggero

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Adolfo García-Sastre

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Natalia Jura

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Mark von Zastrow

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Jack Taunton

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Olivier Schwartz

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Marco Vignuzzi

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Christophe d'Enfert

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Shaeri Mukherjee

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Harmit S Malik

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Danica G Fujimori

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Trey Ideker

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Charles S Craik

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Stephen Floor

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James S Fraser

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John Gross

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Andrej Sali

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2 references

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Brian K Shoichet

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Nevan J Krogan

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66

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Jeffrey Z Guo

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full work available at URL

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publication date

27 March 2020

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2020.03.22.002386

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1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Discovery of XL413, a potent and selective CDC7 inhibitor

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

A quantitative analysis of kinase inhibitor selectivity

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Comprehensive analysis of kinase inhibitor selectivity

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Discovery of potent and selective small-molecule PAR-2 agonists.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Structural insight into allosteric modulation of protease-activated receptor 2.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

The ChEMBL database in 2017

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

ZINC 15--Ligand Discovery for Everyone

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

ATP-competitive inhibitors of mTOR: an update.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Characterization of the cloned full-length and a truncated human target of rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Sigma Receptors as Endoplasmic Reticulum Stress "Gatekeepers" and their Modulators as Emerging New Weapons in the Fight Against Cancer

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2 -binding ability

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Translation control of the immune checkpoint in cancer and its therapeutic targeting

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis

25 July 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239059

25 July 2020

Identifiers

2 references

https://api.crossref.org/v1/works/http://dx.doi.org/10.1101/2020.03.22.002386

27 May 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32511329 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

1125828513

1 reference

Dimensions COVID-19 publications, datasets and clinical trials

28 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32511329 AND SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

32511329

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32511329 AND SRC:MED&resulttype=core&format=json