Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy (Q90657217)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32213135 AND SRC:MED&resulttype=core&format=json

15 April 2020

title

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy (English)

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15 April 2020

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3

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15 April 2020

author name string

Kendall B Wallace

series ordinal

1

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15 April 2020

Vilma A Sardão

series ordinal

2

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15 April 2020

publication date

26 March 2020

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15 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32213135 AND SRC:MED&resulttype=core&format=json

15 April 2020

volume

126

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15 April 2020

issue

7

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15 April 2020

page(s)

926-941

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Sudden death during doxorubicin administration

15 April 2020

cites work

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12 December 2020

Early anthracycline cardiotoxicity

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12 December 2020

AIDS knowledge in three sites in Bas-Zaire

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12 December 2020

The anthracyclines: will we ever find a better doxorubicin?

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12 December 2020

Subcellular distribution of two spin trapping agents in rat heart: possible explanation for their different protective effects against doxorubicin-induced cardiotoxicity

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12 December 2020

Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults

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12 December 2020

Cardiac toxicity 4 to 20 years after completing anthracycline therapy

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12 December 2020

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line

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12 December 2020

Inhibition of transcription by adriamycin is a consequence of the loss of negative superhelicity in DNA mediated by topoisomerase II

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12 December 2020

Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity

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12 December 2020

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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12 December 2020

The potential diagram for oxygen at pH 7.

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12 December 2020

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical

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12 December 2020

Mechanism of inhibition of mitochondrial enzymatic complex I-III by adriamycin derivatives.

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12 December 2020

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase

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12 December 2020

Anthracycline induced myocardial damage. An analysis of 16 autopsy cases

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12 December 2020

Acute arrhythmogenicity of doxorubicin administration

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12 December 2020

Early and delayed clinical cardiotoxicity of doxorubicin

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12 December 2020

A clinicopathologic analysis of adriamycin cardiotoxicity

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12 December 2020

Clinical evaluation of adriamycin, a new antitumour antibiotic

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12 December 2020

Phase I and preliminary phase II evaluation of adriamycin (NSC 123127)

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12 December 2020

The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

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12 December 2020

Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review

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12 December 2020

Adriamycin cardiotoxicity: report of an unusual case with features resembling endomyocardial fibrosis

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12 December 2020

Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin

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12 December 2020

Disruption of mitochondrial calcium homeostasis following chronic doxorubicin administration.

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12 December 2020

Female sex and higher drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer.

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12 December 2020

Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity

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12 December 2020

Myocarditis associated with doxorubicin cardiotoxicity

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12 December 2020

Dose-dependent increase in sensitivity to calcium-induced mitochondrial dysfunction and cardiomyocyte cell injury by doxorubicin

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12 December 2020

Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin

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12 December 2020

Anthracyclines in the treatment of cancer. An overview

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12 December 2020

Electron transport-linked ubiquinone-dependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes

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12 December 2020

Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration 1Supported in part by NIH Grant HL58016. The manuscript was not subjected to internal Agency review and, thus, the opinions are those of the

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12 December 2020

Apoptosis in isolated adult cardiomyocytes exposed to adriamycin

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12 December 2020

Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2 )-ATPase gene transcription

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12 December 2020

Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin

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12 December 2020

What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: threshold expression of mitochondrial defects.

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12 December 2020

Doxorubicin-induced persistent oxidative stress to cardiac myocytes.

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12 December 2020

Interference with calcium-dependent mitochondrial bioenergetics in cardiac myocytes isolated from doxorubicin-treated rats

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12 December 2020

Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers

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12 December 2020

Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity

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12 December 2020

Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review.

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12 December 2020

Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs.

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12 December 2020

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

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12 December 2020

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: relevance to hypoxia/reoxygenation injury

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12 December 2020

Antioxidant nutrients and adriamycin toxicity.

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12 December 2020

The antihypertensive drug carvedilol inhibits the activity of mitochondrial NADH-ubiquinone oxidoreductase

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12 December 2020

Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy

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12 December 2020

Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials

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12 December 2020

The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin

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12 December 2020

Mobilization of adenine nucleotide translocators as molecular bases of the biochemical threshold effect observed in mitochondrial diseases

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12 December 2020

Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism.

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12 December 2020

Annexin V imaging of acute doxorubicin cardiotoxicity (apoptosis) in rats

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12 December 2020

Nuclear receptor signaling and cardiac energetics

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12 December 2020

Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity.

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12 December 2020

Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply

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12 December 2020

Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis.

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12 December 2020

Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice

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12 December 2020

Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity

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12 December 2020

Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction

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12 December 2020

Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study

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12 December 2020

Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats--relevance for mitochondrial dysfunction

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12 December 2020

Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo

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12 December 2020

Carvedilol inhibits mitochondrial oxygen consumption and superoxide production during calcium overload in isolated heart mitochondria

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12 December 2020

Non-invasive monitoring of cardiac hemodynamic parameters in doxorubicin-treated patients: comparison with echocardiography.

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12 December 2020

Early and late arrhythmogenic effects of doxorubicin

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12 December 2020

New iron chelators in anthracycline-induced cardiotoxicity

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12 December 2020

Persistent alterations to the gene expression profile of the heart subsequent to chronic Doxorubicin treatment

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12 December 2020

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease

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12 December 2020

Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts

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12 December 2020

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q

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12 December 2020

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

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12 December 2020

Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling

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12 December 2020

Energetics, epigenetics, mitochondrial genetics

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12 December 2020

Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death

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12 December 2020

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.

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12 December 2020

Doxorubicin induces mitochondrial permeability transition and contractile dysfunction in the human myocardium

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12 December 2020

Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats

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12 December 2020

Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA

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12 December 2020

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

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12 December 2020

Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance

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12 December 2020

Mitochondrial turnover in the heart

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12 December 2020

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

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12 December 2020

Mitochondrial permeability transition in Ca2 -dependent apoptosis and necrosis

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12 December 2020

Doxorubicin-induced cardiac dysfunction is attenuated by ciclosporin treatment in mice through improvements in mitochondrial bioenergetics

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12 December 2020

Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function

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12 December 2020

Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application

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12 December 2020

Mitochondrial regulation of epigenetics and its role in human diseases

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12 December 2020

Adriamycin inhibits adipogenesis through the modulation of PPARγ and restoration of adriamycin-mediated inhibition of adipogenesis by PPARγ over-expression

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12 December 2020

Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific

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12 December 2020

Transcriptional integration of mitochondrial biogenesis

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12 December 2020

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms.

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12 December 2020

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

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12 December 2020

Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models

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12 December 2020

Humanin: a harbinger of mitochondrial-derived peptides?

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12 December 2020

Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor δ Expression in Rats

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12 December 2020

Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat

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12 December 2020

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

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12 December 2020

Role of lysines in cytochrome c-cardiolipin interaction

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12 December 2020

Activation of the p38 MAPK/NF-κB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cells

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12 December 2020

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

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12 December 2020

Salidroside improves doxorubicin-induced cardiac dysfunction by suppression of excessive oxidative stress and cardiomyocyte apoptosis

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12 December 2020

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models.

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12 December 2020

Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor

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12 December 2020

Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts

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12 December 2020

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

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12 December 2020

Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK.

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12 December 2020

Mitochondrial damage-associated molecular patterns and vascular function

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12 December 2020

Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies

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12 December 2020

Effects of short-term endurance exercise training on acute doxorubicin-induced FoxO transcription in cardiac and skeletal muscle

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12 December 2020

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

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12 December 2020

Autosis and autophagic cell death: the dark side of autophagy

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12 December 2020

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

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12 December 2020

Effects of PPARα/PGC-1α on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice

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12 December 2020

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms

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12 December 2020

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

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12 December 2020

A metabolomic study of rats with doxorubicin-induced cardiomyopathy and Shengmai injection treatment

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12 December 2020

Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy

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12 December 2020

Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts

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12 December 2020

Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity

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12 December 2020

p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts.

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12 December 2020

(1)H NMR based metabolomic profiling revealed doxorubicin-induced systematic alterations in a rat model

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12 December 2020

Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro

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12 December 2020

Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice

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12 December 2020

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.

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12 December 2020

Epigenetics in heart failure phenotypes

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12 December 2020

Mitochondrial health, the epigenome and healthspan

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12 December 2020

Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

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12 December 2020

Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

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12 December 2020

Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity

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12 December 2020

Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca2 in Human Cardiac Progenitor Cells

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12 December 2020

Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria

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12 December 2020

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

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12 December 2020

UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity

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12 December 2020

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes

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12 December 2020

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity.

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12 December 2020

Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling.

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12 December 2020

Metabolic Reprogramming via PPARα Signaling in Cardiac Hypertrophy and Failure From Metabolomics to Epigenetics.

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12 December 2020

Early transcriptional alteration of histone deacetylases in a murine model of doxorubicin-induced cardiomyopathy

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12 December 2020

Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT.

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12 December 2020

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts.

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12 December 2020

High Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure

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12 December 2020

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

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12 December 2020

The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway

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12 December 2020

The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT.

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12 December 2020

Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium

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12 December 2020

Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier

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12 December 2020

PGC-1: The Energetic Regulator in Cardiac Metabolism

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12 December 2020

Thrombopoietin protects H9C2 cells from excessive autophagy and apoptosis in doxorubicin-induced cardiotoxicity

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12 December 2020

Programmed necrosis in heart disease: Molecular mechanisms and clinical implications

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12 December 2020

Effects of Resistance Exercise Training on Doxorubicin-Induced Cardiotoxicity.

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12 December 2020

Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment.

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12 December 2020

Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity

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12 December 2020

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

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12 December 2020

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

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12 December 2020

HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy

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12 December 2020

Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway

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12 December 2020

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

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12 December 2020

The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy.

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12 December 2020

Humanin Analogue (HNG) Enhances the Protective Effect of Dexrazoxane against Doxorubicin-induced Cardiotoxicity.

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12 December 2020

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.

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12 December 2020

Left Ventricular Mass Change After Anthracycline Chemotherapy

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12 December 2020

MicroRNA-29b Regulates the Mitochondria-Dependent Apoptotic Pathway by Targeting Bax in Doxorubicin Cardiotoxicity

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12 December 2020

Cardiovascular disease in survivors of childhood cancer

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12 December 2020

Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

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12 December 2020

Protective Effects of a Novel Agonist of Galanin Receptors Against Doxorubicin-Induced Cardiotoxicity in Rats

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12 December 2020

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass

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12 December 2020

Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis

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12 December 2020

Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes

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12 December 2020

Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice

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12 December 2020

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

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12 December 2020

Berberine protects myocardial cells against anoxia-reoxygenation injury via p38 MAPK-mediated NF-κB signaling pathways

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12 December 2020

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

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12 December 2020

Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1

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12 December 2020

Effects of Calorie Restriction and Voluntary Exercise on Doxorubicin-Induced Cardiotoxicity

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12 December 2020

MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1

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12 December 2020

The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes

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12 December 2020