The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro (Q90644845)

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15 April 2020

title

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro (English)

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5

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Volker M. Arlt

11

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9

Marie Stiborová

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author name string

Mateja Sborchia

1

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Eric G De Prez

2

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15 April 2020

Marie-Hélène Antoine

3

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Lucie Bienfait

4

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Gabriel Valbuena

6

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David H Phillips

7

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Joëlle L Nortier

8

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Hector C Keun

10

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publication date

10 October 2019

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published in

Archives of Toxicology

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volume

93

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issue

11

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page(s)

3345-3366

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

15 April 2020

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Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells

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Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats

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Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

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Bench-to-bedside review: lactate and the kidney

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Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi).

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Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy

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Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

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Acute nephrotoxicity of aristolochic acids in mice

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DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy

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Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy

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Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

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12 December 2020

Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes

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12 December 2020

Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences

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12 December 2020

Analytical strategies in metabonomics

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12 December 2020

Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat

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12 December 2020

p53 in health and disease

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12 December 2020

Selective toxicity of aristolochic acids I and II.

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12 December 2020

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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12 December 2020

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

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12 December 2020

Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts

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12 December 2020

Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation

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12 December 2020

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

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12 December 2020

Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up

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12 December 2020

Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53.

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12 December 2020

TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

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Chemical and molecular basis of the carcinogenicity of Aristolochia plants

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12 December 2020

Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on bibliographic sources

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Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

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12 December 2020

When mutants gain new powers: news from the mutant p53 field.

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12 December 2020

H2AX: functional roles and potential applications

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12 December 2020

Activation of p53 promotes renal injury in acute aristolochic acid nephropathy

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12 December 2020

TP53 mutations in human cancers: origins, consequences, and clinical use

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12 December 2020

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

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12 December 2020

Mouse models of p53 functions

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12 December 2020

Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cells.

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12 December 2020

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

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12 December 2020

Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats

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12 December 2020

Nuclear Magnetic Resonance (NMR)-Based Metabolomics

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12 December 2020

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

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12 December 2020

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

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12 December 2020

Physiological and molecular characterization of aristolochic acid transport by the kidney

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12 December 2020

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12 December 2020

Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes

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12 December 2020

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

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12 December 2020

Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I

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12 December 2020

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

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12 December 2020

Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts

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12 December 2020

Aristolochic acid-associated urothelial cancer in Taiwan

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12 December 2020

Mutant p53: one name, many proteins

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12 December 2020

Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy

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12 December 2020

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

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12 December 2020

Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania.

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12 December 2020

Pharmaceuticals. Volume 100 A. A review of human carcinogens

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12 December 2020

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease

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12 December 2020

The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review

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12 December 2020

A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutation

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12 December 2020

Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.

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12 December 2020

³²P-postlabeling analysis of DNA adducts

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12 December 2020

Proximal tubule function and response to acidosis

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12 December 2020

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool

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12 December 2020

Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing

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12 December 2020

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.

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12 December 2020

Insights into wild-type and mutant p53 functions provided by genetically engineered mice

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The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats

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12 December 2020

³²P-postlabeling analysis of DNA adducts.

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12 December 2020

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.

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12 December 2020

Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation

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12 December 2020

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

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12 December 2020

Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion

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12 December 2020

Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

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12 December 2020

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.

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12 December 2020

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

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12 December 2020

Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS.

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12 December 2020

Review series: The cell biology of renal filtration

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12 December 2020

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53( / ), Trp53( /-) and Trp53(-/-) mice

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12 December 2020

Revisiting Protocols for the NMR Analysis of Bacterial Metabolomes

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12 December 2020

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

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12 December 2020

Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy

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12 December 2020

Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53( / ),Trp53( /-) and Trp53(-/-) mice

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12 December 2020

The genome as a record of environmental exposure

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12 December 2020

Aristolochic acid exposure in Romania and implications for renal cell carcinoma

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12 December 2020

Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes

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12 December 2020

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

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12 December 2020

Balkan endemic nephropathy: an update on its aetiology

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12 December 2020

Aristolochic Acid in the Etiology of Renal Cell Carcinoma

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12 December 2020

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

1 reference

12 December 2020

Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats

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12 December 2020

An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature

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12 December 2020

Assessment of metabolic phenotypic variability in children's urine using 1H NMR spectroscopy

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12 December 2020

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

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12 December 2020

Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics

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12 December 2020

Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure.

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12 December 2020

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease

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12 December 2020

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer

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12 December 2020

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53( / ), TP53( /-) and TP53(-/-) cells

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12 December 2020

The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells

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12 December 2020

A Compendium of Mutational Signatures of Environmental Agents

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12 December 2020

Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid

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12 December 2020

Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro

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12 December 2020

10.1007/S00204-019-02578-4

Identifiers

DOI

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PubMed publication ID

31602497

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