Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801 (Q90609526)

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15 April 2020

title

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801 (English)

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15 April 2020

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7

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Kevin J. Saliba

8

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15 April 2020

Willem A. Van Otterlo

9

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Erick Strauss

10

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author name string

Riyad Domingo

1

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15 April 2020

Renier van der Westhuyzen

2

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Anton R Hamann

3

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Konrad J Mostert

4

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Leanne Barnard

5

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Tanya Paquet

6

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publication date

17 October 2019

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volume

10

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issue

12

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page(s)

2118-2125

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CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.

15 April 2020

cites work

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12 December 2020

Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.

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12 December 2020

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation

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12 December 2020

Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with Dess-Martin periodinane

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12 December 2020

Hydrogen-bond-directed highly stereoselective synthesis of Z-enamides via Pd-catalyzed oxidative amidation of conjugated olefins

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12 December 2020

Mechanism of intracellular block of the KcsA K channel by tetrabutylammonium: insights from X-ray crystallography, electrophysiology and replica-exchange molecular dynamics simulations

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12 December 2020

Operationally simple and efficient workup procedure for TBAF-mediated desilylation: application to halichondrin synthesis

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12 December 2020

An efficient approach to the stereocontrolled synthesis of enamides

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12 December 2020

Development of a novel Pd-catalyzed N-acyl vinylogous carbamate synthesis for the key intermediate of ICE inhibitor VX-765

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12 December 2020

Coenzyme A biosynthesis: an antimicrobial drug target

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12 December 2020

[4 2] Cycloaddition reactions catalyzed by a chiral oxazaborolidinium cation. Reaction rates and diastereo-, regio-, and enantioselectivity depend on whether both bonds are formed simultaneously

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12 December 2020

Fast and flexible synthesis of pantothenic acid and CJ-15,801

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12 December 2020

Use of Catalytic Fluoride under Neutral Conditions for Cleaving Silicon–Oxygen Bonds

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12 December 2020

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

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12 December 2020

Enantioselective Synthesis of Allylboronates and Allylic Alcohols by Copper-Catalyzed 1,6-Boration

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12 December 2020

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

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12 December 2020

Novel pantothenate derivatives for anti-malarial chemotherapy

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12 December 2020

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

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12 December 2020

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

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12 December 2020

Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation

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12 December 2020

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

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12 December 2020

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

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12 December 2020

Identifiers

DOI

10.1039/C9MD00312F

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15 April 2020

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