SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation (Q90474751)

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14 April 2020

title

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation (English)

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14 April 2020

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4

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14 April 2020

author name string

Peter M Haggie

1

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14 April 2020

Onur Cil

2

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14 April 2020

Sujin Lee

3

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14 April 2020

Amber A Rivera

5

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14 April 2020

Puay-Wah Phuan

6

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14 April 2020

Alan S Verkman

7

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publication date

26 July 2018

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14 April 2020

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volume

3

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14 April 2020

issue

14

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Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas

14 April 2020

cites work

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12 December 2020

The down-regulated in adenoma (DRA) gene encodes an intestine-specific membrane glycoprotein

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12 December 2020

Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea

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12 December 2020

Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene

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Renal and intestinal absorptive defects in mice lacking the NHE3 Na /H exchanger

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12 December 2020

Loss of the NHE2 Na( )/H( ) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice

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12 December 2020

Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine

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12 December 2020

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

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12 December 2020

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6

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12 December 2020

Long-term clinical outcome in patients with congenital chloride diarrhea

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12 December 2020

slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon

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12 December 2020

PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum

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12 December 2020

Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice

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12 December 2020

The solute carrier 26 family of proteins in epithelial ion transport

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12 December 2020

Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine

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12 December 2020

Diverse transport modes by the solute carrier 26 family of anion transporters

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12 December 2020

Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum

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12 December 2020

Chemical probes that competitively and selectively inhibit Stat3 activation

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12 December 2020

Review article: the clinical management of congenital chloride diarrhoea

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12 December 2020

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population

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12 December 2020

Segregation of Na/H exchanger-3 and Cl/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon

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12 December 2020

Functional activity of Pat‐1 (Slc26a6) Cl−/HCO3− exchange in the lower villus epithelium of murine duodenum

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12 December 2020

Regulation of electroneutral NaCl absorption by the small intestine

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12 December 2020

Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl−/1HCO3− exchange

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12 December 2020

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

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12 December 2020

Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation

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12 December 2020

Update on SLC26A3 mutations in congenital chloride diarrhea

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12 December 2020

Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities

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12 December 2020

The SLC26 gene family of anion transporters and channels

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12 December 2020

Review on natural coumarin lead compounds for their pharmacological activity

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12 December 2020

Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate

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12 December 2020

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.

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12 December 2020

The role of pendrin in renal physiology

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12 December 2020

Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea

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12 December 2020

Role of epithelial ion transports in inflammatory bowel disease

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12 December 2020

Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

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12 December 2020

Diagnosis and management of chronic constipation in adults

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12 December 2020

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation

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12 December 2020

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide

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12 December 2020

Gastrointestinal Manifestations of Cystic Fibrosis

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12 December 2020

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

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12 December 2020

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

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12 December 2020

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

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12 December 2020

Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial

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12 December 2020

A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR.

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12 December 2020

Existing and emerging therapies for managing constipation and diarrhea

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12 December 2020

Chronic constipation.

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12 December 2020

10.1172/JCI.INSIGHT.121370

Identifiers

DOI

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14 April 2020

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14 April 2020

PubMed publication ID

30046015

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