Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects (Q90452439)

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14 April 2020

title

Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects (English)

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14 April 2020

author name string

John E Donello

1

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14 April 2020

Pradeep Banerjee

2

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14 April 2020

Yong-Xin Li

3

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14 April 2020

Yuan-Xing Guo

4

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14 April 2020

Takashi Yoshitake

5

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14 April 2020

Xiao-Lei Zhang

6

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14 April 2020

Omid Miry

7

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14 April 2020

Jan Kehr

8

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14 April 2020

Patric K Stanton

9

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14 April 2020

Amanda L Gross

10

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14 April 2020

Jeffery S Burgdorf

11

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14 April 2020

Roger A Kroes

12

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14 April 2020

Joseph R Moskal

13

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publication date

1 March 2019

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The International Journal of Neuropsychopharmacology

14 April 2020

published in

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volume

22

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issue

3

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page(s)

247-259

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Creative Commons Attribution-NonCommercial 4.0 International

14 April 2020

copyright license

start time

13 December 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

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GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects

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Long-lasting changes in hippocampal synaptic plasticity and cognition in an animal model of NMDA receptor dysfunction in psychosis

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12 December 2020

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

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Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function

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Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics

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Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

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12 December 2020

Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.

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12 December 2020

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.

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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

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GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice

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12 December 2020

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

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GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

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12 December 2020

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

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12 December 2020

Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept

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12 December 2020

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy.

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Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

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12 December 2020

Identifiers

DOI

10.1093/IJNP/PYY101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30544218 AND SRC:MED&resulttype=core&format=json

14 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30544218 AND SRC:MED&resulttype=core&format=json

14 April 2020

PubMed publication ID

30544218

1 reference