Sepsis therapies: learning from 30 years of failure of translational research to propose new leads (Q90354681)

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13 April 2020

review article

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title

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads (English)

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13 April 2020

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1

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13 April 2020

Tomasz Skirecki

series ordinal

3

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13 April 2020

author name string

Mervyn Singer

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2

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13 April 2020

publication date

16 March 2020

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13 April 2020

published in

EMBO Molecular Medicine

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13 April 2020

volume

12

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13 April 2020

issue

4

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13 April 2020

page(s)

e10128

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Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

13 April 2020

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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

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The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

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Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

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Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection

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Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

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12 December 2020

Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock

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Functional comparison of innate immune signaling pathways in primates

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Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes.

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12 December 2020

Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock

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Muscle weakness in septic patients requiring mechanical ventilation: Protective effect of transcutaneous neuromuscular electrical stimulation

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Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury

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HMGB1 mediates cognitive impairment in sepsis survivors

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Unstressing intemperate models: how cold stress undermines mouse modeling

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Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care

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Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

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Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

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The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia

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Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study

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Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms.

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12 December 2020

Cecal ligation and puncture-induced murine sepsis does not cause lung injury.

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12 December 2020

Sustained and incomplete recovery of naive CD8 T cell precursors after sepsis contributes to impaired CD8 T cell responses to infection

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Identification and description of a novel murine model for polytrauma and shock

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Genomic responses in mouse models poorly mimic human inflammatory diseases

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Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

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Symptoms of Depression in Survivors of Severe Sepsis

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Comparative Analysis of Monocyte Subsets in the Pig

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Validating therapeutic targets through human genetics

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Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury

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The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

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CD39 improves survival in microbial sepsis by attenuating systemic inflammation

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Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis.

1 reference

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Endothelial barrier dysfunction in septic shock

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12 December 2020

Sepsis attenuates the anabolic response to skeletal muscle contraction

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12 December 2020

Cognitive decline after sepsis

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12 December 2020

Neutrophil extracellular traps in patients with sepsis

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12 December 2020

Neutrophils scan for activated platelets to initiate inflammation.

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12 December 2020

Developing a clinically feasible personalized medicine approach to pediatric septic shock

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How informative is the mouse for human gut microbiota research?

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12 December 2020

Profound endothelial damage predicts impending organ failure and death in sepsis

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12 December 2020

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis

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12 December 2020

Readmission diagnoses after hospitalization for severe sepsis and other acute medical conditions.

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Stress disorders following prolonged critical illness in survivors of severe sepsis

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A novel host-proteome signature for distinguishing between acute bacterial and viral infections

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Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function.

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Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

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Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

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Hospitalization Type and Subsequent Severe Sepsis

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The future of murine sepsis and trauma research models

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Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure

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Clinical review: intensive care unit acquired weakness

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A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

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The metabolic phenotype of rodent sepsis: cause for concern?

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Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

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The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

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Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone

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Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial

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The immunoprotective activity of interleukin-33 in mouse model of cecal ligation and puncture-induced sepsis

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The Role of Energy Regulation in the Tubular Epithelial Cell Response to Sepsis.

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Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy.

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Metagenomic Analysis Reveals Dynamic Changes of Whole Gut Microbiota in the Acute Phase of Intensive Care Unit Patients

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Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology

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Evaluation of the FilmArray Blood Culture Identification Panel: Results of a Multicenter Controlled Trial

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Defining immunological dysfunction in sepsis: A requisite tool for precision medicine

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Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis

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LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

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Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum.

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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

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Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

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Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

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12 December 2020

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

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12 December 2020

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

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12 December 2020

The impairment of small nerve fibers in severe sepsis and septic shock

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12 December 2020

Hospital Incidence and Mortality Rates of Sepsis

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12 December 2020

The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness

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12 December 2020

Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies

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12 December 2020

Normalizing the environment recapitulates adult human immune traits in laboratory mice

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12 December 2020

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface

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12 December 2020

The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study

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12 December 2020

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock

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12 December 2020

Comparison of sepsis rats induced by caecal ligation puncture or Staphylococcus aureus using a LC-QTOF-MS metabolomics approach

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12 December 2020

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.

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Preventive strategies and potential therapeutic interventions for delirium in sepsis

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12 December 2020

Neuroanatomy and Physiology of Brain Dysfunction in Sepsis

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12 December 2020

NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation

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12 December 2020

Preventive effects of kilohertz frequency electrical stimulation on sepsis-induced muscle atrophy

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12 December 2020

Mechanisms of Intestinal Barrier Dysfunction in Sepsis

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12 December 2020

The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update

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12 December 2020

Microbiome-wide association studies link dynamic microbial consortia to disease

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12 December 2020

The Early Expression of HLA-DR and CD64 Myeloid Markers Is Specifically Compartmentalized in the Blood and Lungs of Patients with Septic Shock.

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12 December 2020

Moving From Disease-Centered to Patient Goals-Directed Care for Patients With Multiple Chronic Conditions: Patient Value-Based Care.

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12 December 2020

Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis.

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Treatment of endotoxaemia and septicaemia in the equine patient

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Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia.

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Antibiotic use and microbiome function

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Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

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Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis.

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Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis

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Septic encephalopathy and septic encephalitis‬‬.

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Coagulation and sepsis

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The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study.

1 reference

12 December 2020

Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis?

1 reference

12 December 2020

Disruption of the microbiota across multiple body sites in critically ill children

1 reference

12 December 2020

Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

1 reference

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Simplification of a Septic Shock Endotyping Strategy for Clinical Application

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12 December 2020

New insights into the gut as the driver of critical illness and organ failure

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12 December 2020

Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis

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12 December 2020

Simultaneous targeting of CD14 and factor XIa by a fusion protein consisting of an anti-CD14 antibody and the modified second domain of bikunin improves survival in rabbit sepsis models

1 reference

12 December 2020

Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis

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12 December 2020

Sepsis and Immunosenescence in the Elderly Patient: A Review

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12 December 2020

Starving for survival-how catabolic metabolism fuels immune function

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12 December 2020

Cellular and extracellular miRNAs are blood-compartment-specific diagnostic targets in sepsis.

1 reference

12 December 2020

The gut microbiota as a modulator of innate immunity during melioidosis

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12 December 2020

Potentially modifiable factors contributing to sepsis-associated encephalopathy

1 reference

12 December 2020

Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice

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12 December 2020

Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response

1 reference

12 December 2020

MicroRNA-155 attenuates late sepsis-induced cardiac dysfunction through JNK and β-arrestin 2.

1 reference

12 December 2020

Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels

1 reference

12 December 2020

Metabolic Adaptation Establishes Disease Tolerance to Sepsis

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12 December 2020

Recognizing Sepsis as a Global Health Priority - A WHO Resolution

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12 December 2020

Sepsis-Associated Encephalopathy: The Blood-Brain Barrier and the Sphingolipid Rheostat

1 reference

12 December 2020

A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification.

1 reference

12 December 2020

Increased healthcare facility use in veterans surviving sepsis hospitalization

1 reference

12 December 2020

Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis

1 reference

12 December 2020

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes.

1 reference

12 December 2020

Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness

1 reference

12 December 2020

Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice

1 reference

12 December 2020

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

1 reference

12 December 2020

Stem Cell-based Therapies for Sepsis

1 reference

12 December 2020

Long-term risk of seizures in adult survivors of sepsis

1 reference

12 December 2020

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

1 reference

12 December 2020

Evidence for Persistent Immune Suppression in Patients WHO Develop Chronic Critical Illness After Sepsis

1 reference

12 December 2020

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.

1 reference

12 December 2020

Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

1 reference

12 December 2020

Pediatric Sepsis Endotypes Among Adults With Sepsis

1 reference

12 December 2020

Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve

1 reference

12 December 2020

Exotoxins and endotoxins: Inducers of inflammatory cytokines

1 reference

12 December 2020

Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study.

1 reference

12 December 2020

Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model.

1 reference

12 December 2020

Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database.

1 reference

12 December 2020

Risk of Subsequent Sepsis within 90 Days of a Previous Hospital Stay by Type of Antibiotic Exposure

1 reference

12 December 2020

The microbiota protects against respiratory infection via GM-CSF signaling

1 reference

12 December 2020

Endocrine and Metabolic Alterations in Sepsis and Implications for Treatment

1 reference

12 December 2020

Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway

1 reference

12 December 2020

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

1 reference

12 December 2020

Compartment diversity in innate immune reprogramming

1 reference

12 December 2020

Enhancing Recovery From Sepsis: A Review

1 reference

12 December 2020

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

1 reference

12 December 2020

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

1 reference

12 December 2020

A community approach to mortality prediction in sepsis via gene expression analysis.

1 reference

12 December 2020

Protracted immune disorders at one year after ICU discharge in patients with septic shock.

1 reference

12 December 2020

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.

1 reference

12 December 2020

Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

1 reference

12 December 2020

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

1 reference

12 December 2020

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

1 reference

12 December 2020

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

1 reference

12 December 2020

Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.

1 reference

12 December 2020

Validation of a Host Response Assay, Septicyte™ LAB, for Discriminating Sepsis from SIRS in the ICU.

1 reference

12 December 2020

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).

1 reference

12 December 2020

Current understanding of the human microbiome.

1 reference

12 December 2020

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.

1 reference

12 December 2020

Molecular and Functional Neuroscience in Immunity.

1 reference

12 December 2020

Long-Term Cognitive Outcomes After Sepsis: a Translational Systematic Review

1 reference

12 December 2020

Mechanisms and treatment of organ failure in sepsis.

1 reference

12 December 2020

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

1 reference

12 December 2020

Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis.

1 reference

12 December 2020

Adipose-derived mesenchymal stem cell-derived exosomes alleviate overwhelming systemic inflammatory reaction and organ damage and improve outcome in rat sepsis syndrome.

1 reference

12 December 2020

Endothelial Activation: The Ang/Tie Axis in Sepsis.

1 reference

12 December 2020

Interleukin 38 Protects Against Lethal Sepsis

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12 December 2020

Pro-inflammatory activation of microglia in the brain of patients with sepsis.

1 reference

12 December 2020

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects

1 reference

12 December 2020

Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients.

1 reference

12 December 2020

Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation

1 reference

12 December 2020

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.

1 reference

12 December 2020

Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection

1 reference

12 December 2020

Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial

1 reference

12 December 2020

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study

1 reference

12 December 2020

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

1 reference

12 December 2020

Molecular Regulation of Acute Tie2 Suppression in Sepsis

1 reference

12 December 2020

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

1 reference

12 December 2020

TORC1 inhibition enhances immune function and reduces infections in the elderly

1 reference

12 December 2020

Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective.

1 reference

12 December 2020

Arguing for Adaptive Clinical Trials in Sepsis.

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12 December 2020

Hemophagocytic Lymphohistiocytosis: Potentially Underdiagnosed in Intensive Care Units

1 reference

12 December 2020

Human skin commensals augment Staphylococcus aureus pathogenesis

1 reference

12 December 2020

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

1 reference

12 December 2020

Neuroimaging Findings in Sepsis-Induced Brain Dysfunction: Association with Clinical and Laboratory Findings

1 reference

12 December 2020

Electroacupuncture Improves Intestinal Dysfunction in Septic Patients: A Randomised Controlled Trial

1 reference

12 December 2020

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

1 reference

12 December 2020

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

1 reference

12 December 2020

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

1 reference

12 December 2020

Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study

1 reference

12 December 2020

The Role of Epigenetic Alterations Involved in Sepsis: An Overview

1 reference

12 December 2020

Immunosuppression is Inappropriately Qualifying the Immune Status of Septic and SIRS Patients

1 reference

12 December 2020

Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay

1 reference

12 December 2020

Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial

1 reference

12 December 2020

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial

1 reference

12 December 2020

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

1 reference

12 December 2020

Extracorporeal cytokine adsorption in septic shock: A proof of concept randomized, controlled pilot study

1 reference

12 December 2020

Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559)

1 reference

12 December 2020

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial

1 reference

12 December 2020

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin conce

1 reference

12 December 2020

Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

1 reference

12 December 2020

Glucose control in the ICU

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12 December 2020

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

1 reference

12 December 2020

Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival

1 reference

12 December 2020

Redefine statistical significance

1 reference

12 December 2020

Influences of stress hormones on microbial infections

1 reference

12 December 2020

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

1 reference

12 December 2020

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

1 reference

12 December 2020

Role of ghrelin on growth hormone/insulin-like growth factor-1 axis during endotoxemia

1 reference

12 December 2020

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

1 reference

12 December 2020

Current gaps in sepsis immunology: new opportunities for translational research

1 reference

12 December 2020

Sepsis hysteria: excess hype and unrealistic expectations

1 reference

12 December 2020

Do critical care patients hibernate? Theoretical support for less is more

1 reference

12 December 2020

Ghrelin alterations during experimental and human sepsis

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12 December 2020

Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study

1 reference

12 December 2020