Resistance Mechanisms to Anti-angiogenic Therapies in Cancer (Q90347558)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

review article

1 reference

title

Resistance Mechanisms to Anti-angiogenic Therapies in Cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

main subject

angiogenesis inhibitor

1 reference

Yolla Haibe

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

Malek Kreidieh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

Hiba El Hajj

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

Ibrahim Khalifeh

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

Deborah Mukherji

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

Sally Temraz

6

1 reference

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13 April 2020

Ali Shamseddine

7

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13 April 2020

publication date

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

published in

Frontiers in Oncology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

volume

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

page(s)

221

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 April 2020

copyright license

start time

27 February 2020

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma.

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Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma

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Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

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G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

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Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts.

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Environment-mediated drug resistance: a major contributor to minimal residual disease

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Antiangiogenic therapies for high-grade glioma

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Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies

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Signalling pathways in vasculogenic mimicry

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Bridges that guide and unite

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HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis

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A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts

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Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis

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Anti-VEGF/VEGFR therapy for cancer: reassessing the target

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Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors

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Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors

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Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

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Prognostic factors for overall survival in patients with metastatic colorectal carcinoma treated with vascular endothelial growth factor-targeting agents.

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12 December 2020

VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex

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12 December 2020

Contrasting effects of sunitinib within in vivo models of metastasis

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12 December 2020

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

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12 December 2020

Macrophage plasticity and polarization in tissue repair and remodelling

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Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial

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Class 3 semaphorins: physiological vascular normalizing agents for anti-cancer therapy

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HIFs, angiogenesis, and cancer

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Bevacizumab in stage II-III colon cancer: 5-year update of the National Surgical Adjuvant Breast and Bowel Project C-08 trial

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Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance

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A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer

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A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors.

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A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors

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1 reference

12 December 2020

Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas

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12 December 2020

Angiopoietin signaling in the vasculature

1 reference

12 December 2020

The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages

1 reference

12 December 2020

β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma

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12 December 2020

Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer

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Targeting hypoxia for sensitization of tumors to radio- and chemotherapy

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Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients

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12 December 2020

S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab

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12 December 2020

Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.

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12 December 2020

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

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12 December 2020

Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice

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12 December 2020

Heterogeneity of tumor endothelial cells

1 reference

12 December 2020

Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales

1 reference

12 December 2020

Understanding and targeting resistance to anti-angiogenic therapies

1 reference

12 December 2020

A proangiogenic signature is revealed in FGF-mediated bevacizumab-resistant head and neck squamous cell carcinoma

1 reference

12 December 2020

Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy

1 reference

12 December 2020

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

1 reference

12 December 2020

Neutrophils promote the malignant glioma phenotype through S100A4.

1 reference

12 December 2020

VEGF and pleiotrophin modulate the immune profile of breast cancer

1 reference

12 December 2020

β1 integrin: Critical path to antiangiogenic therapy resistance and beyond

1 reference

12 December 2020

Targeting the PDGF signaling pathway in tumor treatment

1 reference

12 December 2020

Differential antitumor activity of aflibercept and bevacizumab in patient-derived xenograft models of colorectal cancer

1 reference

12 December 2020

Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy

1 reference

12 December 2020

Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy

1 reference

12 December 2020

Treatment of metastatic colorectal cancer with or without bevacizumab: can the neutrophil/lymphocyte ratio predict the efficiency of bevacizumab?

1 reference

12 December 2020

A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study.

1 reference

12 December 2020

CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma

1 reference

12 December 2020

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.

1 reference

12 December 2020

Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis

1 reference

12 December 2020

Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis.

1 reference

12 December 2020

Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas.

1 reference

12 December 2020

Targeting the TGFβ pathway for cancer therapy.

1 reference

12 December 2020

Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia

1 reference

12 December 2020

Dovitinib (TKI258), a multi-target angiokinase inhibitor, is effective regardless of KRAS or BRAF mutation status in colorectal cancer

1 reference

12 December 2020

Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma.

1 reference

12 December 2020

The great escape; the hallmarks of resistance to antiangiogenic therapy.

1 reference

12 December 2020

The Fibroblast Growth Factor signaling pathway

1 reference

12 December 2020

Expression of HIF-1α and Markers of Angiogenesis Are Not Significantly Different in Triple Negative Breast Cancer Compared to Other Breast Cancer Molecular Subtypes: Implications for Future Therapy

1 reference

12 December 2020

Wiring the Vascular Network with Neural Cues: A CNS Perspective

1 reference

12 December 2020

Angiogenesis Revisited: An Overlooked Role of Endothelial Cell Metabolism in Vessel Sprouting

1 reference

12 December 2020

Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab.

1 reference

12 December 2020

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

1 reference

12 December 2020

Evading anti-angiogenic therapy: resistance to anti-angiogenic therapy in solid tumors

1 reference

12 December 2020

Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation

1 reference

12 December 2020

Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: Potential implications of inflammation bowel disease.

1 reference

12 December 2020

Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?

1 reference

12 December 2020

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

1 reference

12 December 2020

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

1 reference

12 December 2020

Inflammatory indexes as predictors of prognosis and bevacizumab efficacy in patients with metastatic colorectal cancer

1 reference

12 December 2020

Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents

1 reference

12 December 2020

Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models

1 reference

12 December 2020

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

1 reference

12 December 2020

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

1 reference

12 December 2020

Semaphorins and their Signaling Mechanisms

1 reference

12 December 2020

Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non-Small-Cell Lung Cancer

1 reference

12 December 2020

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

1 reference

12 December 2020

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy

1 reference

12 December 2020

Prognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysis

1 reference

12 December 2020

Phase II Study of Dovitinib in Patients Progressing on Anti-Vascular Endothelial Growth Factor Therapy

1 reference

12 December 2020

Bevacizumab in Colorectal Cancer: Current Role in Treatment and the Potential of Biosimilars

1 reference

12 December 2020

Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.

1 reference

12 December 2020

Integration of pro- and anti-angiogenic signals by endothelial cells

1 reference

12 December 2020

Therapy for Cancer: Strategy of Combining Anti-Angiogenic and Target Therapies

1 reference

12 December 2020

Current Challenges of Cancer Anti-angiogenic Therapy and the Promise of Nanotherapeutics.

1 reference

12 December 2020

Cabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial.

1 reference

12 December 2020

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

1 reference

12 December 2020

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.

1 reference

12 December 2020

The role of tumor microenvironment in resistance to anti-angiogenic therapy.

1 reference

12 December 2020

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

1 reference

12 December 2020

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.

1 reference

12 December 2020

Unraveling the Role of Angiogenesis in Cancer Ecosystems.

1 reference

12 December 2020

Overview of advances in vasculogenic mimicry - a potential target for tumor therapy

1 reference

12 December 2020

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

1 reference

12 December 2020

New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-angiogenesis Treatment

1 reference

12 December 2020

Tumor angiogenesis: causes, consequences, challenges and opportunities

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2020.00221

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32175278 AND SRC:MED&resulttype=core&format=json

13 April 2020

PubMed publication ID

32175278

1 reference