Influence of Hyperglycemic Conditions on Self-Association of the Alzheimer's Amyloid β (Aβ1-42) Peptide (Q90333278)

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12 April 2020

title

Influence of Hyperglycemic Conditions on Self-Association of the Alzheimer's Amyloid β (Aβ1-42) Peptide (English)

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12 April 2020

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1

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12 April 2020

author name string

Neelanjana Sengupta

series ordinal

2

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12 April 2020

publication date

17 May 2017

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12 April 2020

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12 April 2020

volume

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30023655 AND SRC:MED&resulttype=core&format=json

12 April 2020

issue

5

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12 April 2020

page(s)

2134-2147

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

12 April 2020

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Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

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Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42.

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The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

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12 December 2020

Atomic-level description of amyloid beta-dimer formation

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12 December 2020

Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

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12 December 2020

Characterizations of distinct amyloidogenic conformations of the Abeta (1-40) and (1-42) peptides

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12 December 2020

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12 December 2020

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12 December 2020

The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides

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12 December 2020

The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

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12 December 2020

How do trehalose, maltose, and sucrose influence some structural and dynamical properties of lysozyme? Insight from molecular dynamics simulations

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12 December 2020

Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities

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12 December 2020

Effects of osmolytes on protein folding and aggregation in cells.

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12 December 2020

Mixed macromolecular crowding inhibits amyloid formation of hen egg white lysozyme

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12 December 2020

Intrinsically disordered proteins display no preference for chaperone binding in vivo

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12 December 2020

Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42

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12 December 2020

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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12 December 2020

Crowding effects on diffusion in solutions and cells

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12 December 2020

Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences

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12 December 2020

Role of water in mediating the assembly of Alzheimer amyloid-beta Abeta16-22 protofilaments

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12 December 2020

Guiding protein aggregation with macromolecular crowding

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12 December 2020

The Alzheimer beta-amyloid (Abeta(1-39)) dimer in an implicit solvent

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12 December 2020

Computational simulations of the early steps of protein aggregation

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12 December 2020

PACKMOL: a package for building initial configurations for molecular dynamics simulations.

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12 December 2020

Involvement of toxic AGEs (TAGE) in the pathogenesis of diabetic vascular complications and Alzheimer's disease

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12 December 2020

Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformation

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12 December 2020

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

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12 December 2020

Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers

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12 December 2020

Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3.

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12 December 2020

Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

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12 December 2020

Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape

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12 December 2020

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease

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12 December 2020

Effects of proteins on protein diffusion.

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12 December 2020

Characterizing amyloid‐beta protein misfolding from molecular dynamics simulations with explicit water

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12 December 2020

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

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12 December 2020

The unique Alzheimer's β-amyloid triangular fibril has a cavity along the fibril axis under physiological conditions

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12 December 2020

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

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12 December 2020

Intrinsically disordered proteins from A to Z

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12 December 2020

Protein self-diffusion in crowded solutions

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12 December 2020

Replica exchange molecular dynamics of the thermodynamics of fibril growth of Alzheimer's Aβ42 peptide

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12 December 2020

Atomic-level investigations on the amyloid-β dimerization process and its driving forces in water

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12 December 2020

Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer.

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12 December 2020

Distinct Dimerization for Various Alloforms of the Amyloid-Beta Protein: Aβ1–40, Aβ1–42, and Aβ1–40(D23N)

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12 December 2020

Dimerization of the Full-Length Alzheimer Amyloid β-Peptide (Aβ42) in Explicit Aqueous Solution: A Molecular Dynamics Study

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12 December 2020

Can Alzheimer disease be a form of type 3 diabetes?

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12 December 2020

Impact of chemical heterogeneity on protein self-assembly in water

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12 December 2020

The contrasting effect of macromolecular crowding on amyloid fibril formation

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12 December 2020

Molecular Insight into the Counteraction of Trehalose on Urea-Induced Protein Denaturation Using Molecular Dynamics Simulation

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12 December 2020

Adsorption mechanism and collapse propensities of the full-length, monomeric Aβ(1-42) on the surface of a single-walled carbon nanotube: a molecular dynamics simulation study

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12 December 2020

Collapse of unfolded proteins in a mixture of denaturants

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12 December 2020

Macromolecular crowding modulates the kinetics and morphology of amyloid self-assembly by β-lactoglobulin

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12 December 2020

Critical roles of key domains in complete adsorption of Aβ peptide on single-walled carbon nanotubes: insights with point mutations and MD simulations

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12 December 2020

Influence of crowded cellular environments on protein folding, binding, and oligomerization: biological consequences and potentials of atomistic modeling

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12 December 2020

Collapse of a hydrophobic polymer in a mixture of denaturants.

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12 December 2020

Computationally efficient methodology for atomic-level characterization of dendrimer-drug complexes: a comparison of amine- and acetyl-terminated PAMAM.

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12 December 2020

Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils

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12 December 2020

Glycation exacerbates the neuronal toxicity of β-amyloid.

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12 December 2020

Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.

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12 December 2020

Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy

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12 December 2020

Aβ-AGE aggravates cognitive deficit in rats via RAGE pathway

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12 December 2020

The crowd you're in with: effects of different types of crowding agents on protein aggregation.

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12 December 2020

Early amyloid β-protein aggregation precedes conformational change

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12 December 2020

Molecular analysis of the interaction between staphylococcal virulence factor Sbi-IV and complement C3d.

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12 December 2020

Interaction with the surrounding water plays a key role in determining the aggregation propensity of proteins

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12 December 2020

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions.

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12 December 2020

Dissecting the Effects of Concentrated Carbohydrate Solutions on Protein Diffusion, Hydration, and Internal Dynamics

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12 December 2020

Structural and energetic insight into the cross-seeding amyloid assemblies of human IAPP and rat IAPP.

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12 December 2020

Introduction to intrinsically disordered proteins (IDPs)

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12 December 2020

Ordered water within the collapsed globules of an amyloidogenic intrinsically disordered protein

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12 December 2020

Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study

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12 December 2020

Effects of macromolecular crowding on amyloid beta (16-22) aggregation using coarse-grained simulations

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12 December 2020

Aβ self-association and adsorption on a hydrophobic nanosurface: competitive effects and the detection of small oligomers via electrical response

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12 December 2020

Molecular insights into the role of aqueous trehalose solution on temperature-induced protein denaturation

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12 December 2020

Interfacial interaction and lateral association of cross-seeding assemblies between hIAPP and rIAPP oligomers.

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12 December 2020

Probing immobilization mechanism of alpha-chymotrypsin onto carbon nanotube in organic media by molecular dynamics simulation

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12 December 2020

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies

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12 December 2020

Distinct role of hydration water in protein misfolding and aggregation revealed by fluctuating thermodynamics analysis

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12 December 2020

Intrinsically disordered energy landscapes

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12 December 2020

Polymorphic cross-seeding amyloid assemblies of amyloid-β and human islet amyloid polypeptide

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12 December 2020

Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure.

1 reference

12 December 2020

Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's disease

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12 December 2020

Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases

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12 December 2020

An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations

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12 December 2020

Making Sense of Intrinsically Disordered Proteins

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12 December 2020

Stability of a Recently Found Triple-β-Stranded Aβ1-42 Fibril Motif

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12 December 2020

Confined Water in Amyloid-Competent Oligomers of the Prion Protein.

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12 December 2020

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

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12 December 2020

Comparison of force fields for Alzheimer's A β42: A case study for intrinsically disordered proteins.

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12 December 2020

Conformational features of the Aβ42 peptide monomer and its interaction with the surrounding solvent

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12 December 2020

Glycation induces conformational changes in the amyloid-β peptide and enhances its aggregation propensity: molecular insights

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12 December 2020

Comparison of hydration behavior and conformational preferences of the Trp-cage mini-protein in different rigid-body water models

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12 December 2020

Alzheimer's Protective Cross-Interaction between Wild-Type and A2T Variants Alters Aβ42 Dimer Structure

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12 December 2020

Identifiers

DOI

10.1021/ACSOMEGA.7B00018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30023655 AND SRC:MED&resulttype=core&format=json

12 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30023655 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

30023655

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