Hepatocyte Nuclear Factor 4 Alpha Activation Is Essential for Termination of Liver Regeneration in Mice (Q90296543)

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12 April 2020

title

Hepatocyte Nuclear Factor 4 Alpha Activation Is Essential for Termination of Liver Regeneration in Mice (English)

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12 April 2020

author name string

Ian Huck

1

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12 April 2020

Sumedha Gunewardena

2

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12 April 2020

Regina Espanol-Suner

3

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12 April 2020

Holger Willenbring

4

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12 April 2020

Udayan Apte

5

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publication date

10 March 2019

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volume

70

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issue

2

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page(s)

666-681

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Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

12 April 2020

cites work

1 reference

7 January 2021

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

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Plasticity and expanding complexity of the hepatic transcription factor network during liver development

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An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function

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Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription

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Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α.

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Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression

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Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene.

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Resetting the transcription factor network reverses terminal chronic hepatic failure

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Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

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7 January 2021

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

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Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents

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7 January 2021

Hepatostat: Liver regeneration and normal liver tissue maintenance

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Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer

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7 January 2021

An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis

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7 January 2021

Yes-associated protein/TEA domain family member and hepatocyte nuclear factor 4-alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice

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7 January 2021

Robust cellular reprogramming occurs spontaneously during liver regeneration.

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7 January 2021

Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice

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7 January 2021

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding

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7 January 2021

Increased Activation of the Wnt/β-Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

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Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury

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7 January 2021

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

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Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer

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Tet-On Systems For Doxycycline-inducible Gene Expression.

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Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation

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TGF-β signalling and liver disease.

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A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells

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TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

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7 January 2021

Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis

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ZBTB20 is involved in liver regeneration after partial hepatectomy in mouse

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7 January 2021

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver

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7 January 2021

The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.

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7 January 2021

Emerging role of PLAG1 as a regulator of growth and reproduction

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7 January 2021

Regulation of gene expression in human cancers by TRIM24.

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7 January 2021

Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila

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7 January 2021

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

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7 January 2021

Prolonged oxidative stress down-regulates Early B cell factor 1 with inhibition of its tumor suppressive function against cholangiocarcinoma genesis

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A novel microRNA identified in hepatocellular carcinomas is responsive to LEF1 and facilitates proliferation and epithelial-mesenchymal transition via targeting of NFIX.

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7 January 2021

Immunohistochemical analyses of cell cycle progression and gene expression of biliary epithelial cells during liver regeneration after partial hepatectomy of the mouse

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7 January 2021

Multiple post-translational modifications in hepatocyte nuclear factor 4α

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7 January 2021

Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4α phosphorylation by mass spectrometry.

1 reference

7 January 2021

Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization

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7 January 2021

An Integrated Approach for the Identification of HNF4α-Centered Transcriptional Regulatory Networks During Early Liver Regeneration

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7 January 2021

Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats

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7 January 2021

Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.

1 reference

7 January 2021

Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo

1 reference

7 January 2021

Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice

1 reference

7 January 2021

MYC activation is a hallmark of cancer initiation and maintenance

1 reference

7 January 2021

Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter

1 reference

7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.30405

1 reference

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12 April 2020

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