CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis (Q90292270)

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12 April 2020

title

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis (English)

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1

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Gabriele Stefanzl

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Peter Valent

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author name string

Daniel Wicklein

2

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Gregor Eisenwort

3

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Mohamad Jawhar

4

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Daniela Berger

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Georg Greiner

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Alexandra Boehm

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Christoph Kornauth

9

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Leonhard Muellauer

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Susanne Sehner

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Gregor Hoermann

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Wolfgang R Sperr

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Philipp B Staber

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Ulrich Jaeger

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Johannes Zuber

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Michel Arock

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Udo Schumacher

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Andreas Reiter

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publication date

17 July 2018

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volume

132

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issue

18

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page(s)

1936-1950

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Cell surface structures on human basophils and mast cells: biochemical and functional characterization

12 April 2020

cites work

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12 December 2020

Systemic mastocytosis

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12 December 2020

Further characterization of surface membrane structures expressed on human basophils and mast cells

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Establishment of an immature mast cell line from a patient with mast cell leukemia

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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A case of malignant mastocytosis with circulating mast cell precursors: biologic and phenotypic characterization of the malignant clone.

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Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

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Biology, classification and treatment of human mastocytosis.

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12 December 2020

Neoplastic human tissue mast cells express the adhesion molecule CD44/HCAM

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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12 December 2020

Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis

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Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications

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12 December 2020

A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia

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12 December 2020

Serum soluble CD44 levels for monitoring disease states in acute leukemia and myelodysplastic syndromes.

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12 December 2020

Human bone marrow mast cells from indolent systemic mast cell disease constitutively express increased amounts of the CD63 protein on their surface

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12 December 2020

Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

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12 December 2020

Human mast cells express the hyaluronic-acid-binding isoform of CD44 and adhere to hyaluronic acid

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12 December 2020

CD44 cell adhesion molecules

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12 December 2020

Potential use of serum CD44 as an indicator of tumour progression in acute leukemia

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12 December 2020

Variable expression of activation-linked surface antigens on human mast cells in health and disease

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12 December 2020

Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis

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12 December 2020

Diagnostic criteria and classification of mastocytosis: a consensus proposal

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Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis.

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12 December 2020

Association of the Q576R polymorphism in the interleukin-4 receptor alpha chain with indolent mastocytosis limited to the skin

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12 December 2020

Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival

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12 December 2020

Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells.

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12 December 2020

Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines

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12 December 2020

Cutaneous mastocytosis -- clinical heterogeneity.

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12 December 2020

Increased angiogenesis in the bone marrow of patients with systemic mastocytosis.

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12 December 2020

Detection of novel CD antigens on the surface of human mast cells and basophils

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12 December 2020

Mastocytosis: current concepts in diagnosis and treatment

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12 December 2020

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12 December 2020

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

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12 December 2020

Systemic mastocytosis

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12 December 2020

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 stem/progenitor cells to bone marrow

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12 December 2020

Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms.

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12 December 2020

Elevated levels of soluble CD44 are associated with advanced disease and in vitro proliferation of neoplastic lymphocytes in B-cell chronic lymphocytic leukaemia

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12 December 2020

CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens.

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12 December 2020

Punish the parent not the progeny.

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12 December 2020

Evaluation of normal and neoplastic human mast cells for expression of CD172a (SIRPalpha), CD47, and SHP-1.

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12 December 2020

CD44v6, a target for novel antibody treatment approaches, is frequently expressed in multiple myeloma and associated with deletion of chromosome arm 13q

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12 December 2020

Cell surface membrane antigen phenotype of human gastrointestinal mast cells

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12 December 2020

PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

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12 December 2020

Detection of molecular targets on the surface of CD34 /CD38-- stem cells in various myeloid malignancies.

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12 December 2020

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

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12 December 2020

Elevated levels of serum CD44 and E-cadherin predict an unfavourable outcome in myelodysplastic syndromes

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12 December 2020

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

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12 December 2020

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

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12 December 2020

A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus

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12 December 2020

CD44 and hematologic malignancies.

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12 December 2020

Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells.

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12 December 2020

Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria

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12 December 2020

Chronic myeloid leukemia stem cells

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12 December 2020

Mast cells and mastocytosis

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12 December 2020

Interleukin-13 promoter gene polymorphism -1112C/T is associated with the systemic form of mastocytosis

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12 December 2020

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

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12 December 2020

Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors

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12 December 2020

CD44, a therapeutic target for metastasising tumours

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12 December 2020

Chronic myelogenous leukemia stem cells: What's new?

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Guidelines for the welfare and use of animals in cancer research

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12 December 2020

Serum CD44 levels predict survival in patients with low-risk myelodysplastic syndromes

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12 December 2020

Targeting of leukemia-initiating cells to develop curative drug therapies: straightforward but nontrivial concept.

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12 December 2020

Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.

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12 December 2020

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

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12 December 2020

CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance

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12 December 2020

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

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12 December 2020

Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis

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12 December 2020

Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms

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12 December 2020

Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer

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12 December 2020

CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

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12 December 2020

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12 December 2020

Comprehensive mutational profiling in advanced systemic mastocytosis

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12 December 2020

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma

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12 December 2020

An optimized microRNA backbone for effective single-copy RNAi

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12 December 2020

ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases.

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12 December 2020

Aberrant presentation of HPA-reactive carbohydrates implies Selectin-independent metastasis formation in human prostate cancer

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12 December 2020

Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal

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12 December 2020

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

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12 December 2020

CD52 is a molecular target in advanced systemic mastocytosis.

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12 December 2020

KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis

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12 December 2020

Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia

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12 December 2020

CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells

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Mast Cells, Mastocytosis, and Related Disorders

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12 December 2020

Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V( ) advanced systemic mastocytosis

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12 December 2020

Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology

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KIT D816V-mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression.

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The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

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12 December 2020

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm

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Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

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12 December 2020

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

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12 December 2020

Prognostic significance of elevated serum CD44 levels in patients with oral squamous cell carcinoma

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12 December 2020

10.1182/BLOOD-2018-02-833582

Identifiers

DOI

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PubMed publication ID

30018080

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