Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats (Q90249645)

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scientific article published on 02 March 2020

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English	Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats	scientific article published on 02 March 2020

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12 April 2020

Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats (English)

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12 April 2020

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Ioannis Margaritis

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12 April 2020

Katerina Angelopoulou

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12 April 2020

Sophia Lavrentiadou

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12 April 2020

Ilias C Mavrovouniotis

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12 April 2020

Maria Tsantarliotou

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12 April 2020

Ioannis Taitzoglou

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12 April 2020

Alexandros Theodoridis

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12 April 2020

Aristidis Veskoukis

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12 April 2020

Efthalia Kerasioti

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12 April 2020

Dimitrios Kouretas

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12 April 2020

Ioannis Zervos

11

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12 April 2020

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2 March 2020

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12 April 2020

Journal of biological research (Thessalonike, Greece)

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12 April 2020

27

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12 April 2020

4

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12 April 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-type plasminogen activator and its inhibitor (PAI-1) in plasma in cases of non-insulin-dependent diabetes mellitus (NIDDM)

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of Absorbed Dietary Cholesterol and Cholesterol Synthesized in Small Intestine to Hypercholesterolemia in Diabetic Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalase in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant defense system in diabetic kidney: a time course study

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose reduces generation of plasmin activity by mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in toadfish (Halobactrachus didactylus) cardiac muscle. Acute exposure to vanadate oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes, oxidative stress, and antioxidants: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total antioxidant capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiology of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review on the role of antioxidants in the management of diabetes and its complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activator inhibitor-1 and diabetic nephropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray profiling of gene expression in human adipocytes in response to anthocyanins

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Role for Plasminogen Activator Inhibitor-1 in Obesity: From Pie to PAI?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in oxidative stress but not in antioxidant capacity with advancing stages of chronic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanisms of alloxan- and streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An extra-virgin olive oil rich in polyphenolic compounds has antioxidant effects in OF1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: lessons from the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain- and tissue-dependent induction of plasminogen activator inhibitor-1 gene expression in fasted mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia: a prothrombotic factor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous Antioxidants—Double‐Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the look AHEAD study

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal function in diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term dietary antioxidant cocktail supplementation effectively reduces renal inflammation in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antioxidant effects of a polyphenol-rich grape pomace extract in vitro do not correspond in vivo using exercise as an oxidant stimulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin "saffron" protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and antioxidant defense

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary flaxseed oil and fish oil modulates expression of antioxidant and inflammatory genes with alleviation of protein glycation status and inflammation in liver of streptozotocin-nicotinamide induced diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue oxidative stress induced by patulin and protective effect of crocin

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrophotometric assays for measuring redox biomarkers in blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE ROLE OF GLUCAGON IN THE PATHOPHYSIOLOGY AND MANAGEMENT OF DIABETES.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of crocin on experimental obesity and type-2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vegetable and fruit juice enhances antioxidant capacity and regulates antioxidant gene expression in rat liver, brain and colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial Effect of Aqueous Garlic Extract on Inflammation and Oxidative Stress Status in the Kidneys of Type 1 Diabetic Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of Antioxidant Mechanisms and Reduction of Oxidative Stress in Chickens after the Administration of Drinking Water Enriched with Polyphenolic Powder from Olive Mill Waste Waters

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primer3_masker: integrating masking of template sequence with primer design software.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress - chronic kidney disease - cardiovascular disease: A vicious circle

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of plasminogen activator inhibitor-1 (PAI-1) activity by crocin ameliorates lipopolysaccharide-induced thrombosis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32161725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S40709-020-00114-5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32161725 AND SRC:MED&resulttype=core&format=json

12 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32161725 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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12 April 2020

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