Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy (Q90211754)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31544811 AND SRC:MED&resulttype=core&format=json

12 April 2020

review article

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title

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31544811 AND SRC:MED&resulttype=core&format=json

12 April 2020

6

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12 April 2020

author name string

Larissa Jank

1

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12 April 2020

Carolina Pinto-Espinoza

2

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12 April 2020

Yinghui Duan

3

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12 April 2020

Friedrich Koch-Nolte

4

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12 April 2020

Tim Magnus

5

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12 April 2020

publication date

3 January 2019

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12 April 2020

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12 April 2020

volume

8

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12 April 2020

issue

1

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Creative Commons Attribution 4.0 International

12 April 2020

copyright license

start time

3 January 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor

1 reference

12 December 2020

Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

1 reference

12 December 2020

Interleukin-1 beta mRNA expression in ischemic rat cortex

1 reference

12 December 2020

Single antibody domains as small recognition units: design and in vitro antigen selection of camelized, human VH domains with improved protein stability

1 reference

12 December 2020

Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier

1 reference

12 December 2020

Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats

1 reference

12 December 2020

Inhibition of tumor necrosis factor and amelioration of brain infarction in mice

1 reference

12 December 2020

TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice

1 reference

12 December 2020

Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia

1 reference

12 December 2020

Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.

1 reference

12 December 2020

Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice

1 reference

12 December 2020

Ischemic cell death in brain neurons

1 reference

12 December 2020

Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire

1 reference

12 December 2020

Multiple molecular penumbras after focal cerebral ischemia

1 reference

12 December 2020

Brain tissue responses to ischemia

1 reference

12 December 2020

Role of IL-1alpha and IL-1beta in ischemic brain damage.

1 reference

12 December 2020

Early TNF-alpha levels correlate with ischaemic stroke severity

1 reference

12 December 2020

Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium

1 reference

12 December 2020

Biophysical Properties of Camelid VHHDomains Compared to Those of Human VH3 Domains†

1 reference

12 December 2020

Heavy-chain antibodies in Camelidae; a case of evolutionary innovation

1 reference

12 December 2020

MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture

1 reference

12 December 2020

Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke.

1 reference

12 December 2020

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo

1 reference

12 December 2020

Thrombin-activable fibrinolysis inhibitor levels in the acute phase of ischemic stroke.

1 reference

12 December 2020

Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia

1 reference

12 December 2020

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

1 reference

12 December 2020

Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients

1 reference

12 December 2020

Different cytokine levels in thrombolysis patients as predictors for clinical outcome

1 reference

12 December 2020

The blood-brain barrier: an overview: structure, regulation, and clinical implications

1 reference

12 December 2020

Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia.

1 reference

12 December 2020

Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH

1 reference

12 December 2020

Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons

1 reference

12 December 2020

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

1 reference

12 December 2020

An evidence-based causative classification system for acute ischemic stroke

1 reference

12 December 2020

The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells

1 reference

12 December 2020

P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat.

1 reference

12 December 2020

Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain.

1 reference

12 December 2020

Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

1 reference

12 December 2020

Stroke incidence and prevalence in Europe: a review of available data

1 reference

12 December 2020

Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion

1 reference

12 December 2020

Improving solubility and refolding efficiency of human V(H)s by a novel mutational approach

1 reference

12 December 2020

Generation of heavy-chain-only antibodies in mice

1 reference

12 December 2020

The inflammatory response in stroke

1 reference

12 December 2020

Cytotoxic edema: mechanisms of pathological cell swelling

1 reference

12 December 2020

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

1 reference

12 December 2020

GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier

1 reference

12 December 2020

Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

1 reference

12 December 2020

Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats

1 reference

12 December 2020

Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70

1 reference

12 December 2020

Anakinra for rheumatoid arthritis

1 reference

12 December 2020

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.

1 reference

12 December 2020

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke

1 reference

12 December 2020

Classification of stroke subtypes

1 reference

12 December 2020

Leukocyte recruitment and ischemic brain injury

1 reference

12 December 2020

Differential tumor-targeting abilities of three single-domain antibody formats

1 reference

12 December 2020

Antibody vectors for imaging

1 reference

12 December 2020

Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours.

1 reference

12 December 2020

Microglial activation in stroke: therapeutic targets

1 reference

12 December 2020

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

1 reference

12 December 2020

1 reference

12 December 2020

Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years

1 reference

12 December 2020

The immunology of stroke: from mechanisms to translation

1 reference

12 December 2020

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study

1 reference

12 December 2020

Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier

1 reference

12 December 2020

Engineered single-domain antibodies with high protease resistance and thermal stability

1 reference

12 December 2020

von Willebrand factor: an emerging target in stroke therapy.

1 reference

12 December 2020

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

1 reference

12 December 2020

Roles of chemokine CXCL12 and its receptors in ischemic stroke

1 reference

12 December 2020

Brain imaging in patients with transient ischemic attack: a comparison of computed tomography and magnetic resonance imaging

1 reference

12 December 2020

Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions

1 reference

12 December 2020

Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

1 reference

12 December 2020

The immunology of acute stroke

1 reference

12 December 2020

In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease

1 reference

12 December 2020

Pathophysiologic cascades in ischemic stroke

1 reference

12 December 2020

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

1 reference

12 December 2020

Inflammatory cytokines in experimental and human stroke.

1 reference

12 December 2020

Investigation of the role of FcγR and FcRn in mAb distribution to the brain

1 reference

12 December 2020

Affinity is an important determinant of the anti-trypanosome activity of nanobodies

1 reference

12 December 2020

Detection of vascular cell adhesion molecule-1 expression with USPIO-enhanced molecular MRI in a mouse model of cerebral ischemia

1 reference

12 December 2020

MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent

1 reference

12 December 2020

Nanobodies: natural single-domain antibodies

1 reference

12 December 2020

Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

1 reference

12 December 2020

Inhibition of CXCL12 signaling attenuates the postischemic immune response and improves functional recovery after stroke

1 reference

12 December 2020

TNF-α signalling and inflammation: interactions between old acquaintances

1 reference

12 December 2020

PECAM-1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia

1 reference

12 December 2020

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes

1 reference

12 December 2020

Microglia and ischemic stroke: a double-edged sword

1 reference

12 December 2020

(Dis)solving the stroke problem by vWF inhibition?

1 reference

12 December 2020

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

1 reference

12 December 2020

In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody

1 reference

12 December 2020

Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke

1 reference

12 December 2020

The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

1 reference

12 December 2020

A novel platform for engineering blood-brain barrier-crossing bispecific biologics

1 reference

12 December 2020

Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action.

1 reference

12 December 2020

Molecular magnetic resonance imaging of brain-immune interactions

1 reference

12 December 2020

Leukocyte migration into inflamed tissues.

1 reference

12 December 2020

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

1 reference

12 December 2020

DAMP signaling is a key pathway inducing immune modulation after brain injury.

1 reference

12 December 2020

Tumor necrosis factor inhibitors - state of knowledge

1 reference

12 December 2020

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

1 reference

12 December 2020

Interleukin-1 and acute brain injury

1 reference

12 December 2020

Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor

1 reference

12 December 2020

Targeting neutrophils in ischemic stroke: translational insights from experimental studies.

1 reference

12 December 2020

Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke

1 reference

12 December 2020

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

1 reference

12 December 2020

ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke

1 reference

12 December 2020

Purinergic signalling in brain ischemia.

1 reference

12 December 2020

Targeting of vascular cell adhesion molecule-1 by 18F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques

1 reference

12 December 2020

The blood-brain barrier after stroke: Structural studies and the role of transcytotic vesicles

1 reference

12 December 2020

Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.

1 reference

12 December 2020

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

1 reference

12 December 2020

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

1 reference

12 December 2020

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion.

1 reference

12 December 2020

Nanobodies as therapeutics: big opportunities for small antibodies

1 reference

12 December 2020

Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity

1 reference

12 December 2020

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

1 reference

12 December 2020

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets

1 reference

12 December 2020

Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

1 reference

12 December 2020

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

1 reference

12 December 2020

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

1 reference

12 December 2020

A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain

1 reference

12 December 2020

Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack

1 reference

12 December 2020

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein

1 reference

12 December 2020

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura

1 reference

12 December 2020

Comparison of Three Antihapten VHH Selection Strategies for the Development of Highly Sensitive Immunoassays for Microcystins

1 reference

12 December 2020

Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease

1 reference

12 December 2020

Nanobody Technology: A Versatile Toolkit for Microscopic Imaging, Protein-Protein Interaction Analysis, and Protein Function Exploration.

1 reference

12 December 2020

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome

1 reference

12 December 2020

Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions

1 reference

12 December 2020

Strategies to Improve Stroke Care Services in Low- and Middle-Income Countries: A Systematic Review.

1 reference

12 December 2020

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.

1 reference

12 December 2020

TNFR1 inhibition with a Nanobody protects against EAE development in mice

1 reference

12 December 2020

Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment

1 reference

12 December 2020

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.

1 reference

12 December 2020

Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

1 reference

12 December 2020

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

1 reference

12 December 2020

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation.

1 reference

12 December 2020

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

1 reference

12 December 2020

MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.

1 reference

12 December 2020

The structural basis of nanobody unfolding reversibility and thermoresistance.

1 reference

12 December 2020

Post-ischaemic administration of the murine Canakinumab-surrogate antibody improves outcome in experimental stroke

1 reference

12 December 2020

Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke

1 reference

12 December 2020

Caplacizumab: First Global Approval

1 reference

12 December 2020

Identifiers

DOI

10.3390/ANTIB8010005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31544811 AND SRC:MED&resulttype=core&format=json

12 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31544811 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

31544811

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