Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice (Q89833709)

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8 April 2020

title

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice (English)

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2

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Kellie R. Machlus

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15

James E Bear

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13

Joseph E Italiano

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author name string

David S Paul

1

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Congying Wu

3

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Raymond Piatt

4

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Swetha Pasala

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Robert A Campbell

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Kathryn O Poe

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Dorsaf Ghalloussi

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Robert H Lee

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Jeremy D Rotty

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Brian C Cooley

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Andrew S Weyrich

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Wolfgang Bergmeier

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publication date

1 August 2017

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volume

1

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issue

18

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page(s)

1398-1408

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Arp2/3 complex is required for actin polymerization during platelet shape change

8 April 2020

cites work

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12 December 2020

Platelet ITAM signaling is critical for vascular integrity in inflammation

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12 December 2020

Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

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12 December 2020

Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model

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12 December 2020

Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI.

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12 December 2020

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

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12 December 2020

Rho GTPases in platelet function

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12 December 2020

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

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12 December 2020

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.

1 reference

12 December 2020

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect

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12 December 2020

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.

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12 December 2020

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery

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12 December 2020

New insights into the regulation and cellular functions of the ARP2/3 complex

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12 December 2020

Lamellipodia are crucial for haptotactic sensing and response

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12 December 2020

Glycosylation restores survival of chilled blood platelets

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12 December 2020

A multiinstitutional survey of the Wiskott-Aldrich syndrome.

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12 December 2020

Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein

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12 December 2020

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis

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12 December 2020

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

1 reference

12 December 2020

Rac1 is essential for phospholipase C-gamma2 activation in platelets

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12 December 2020

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

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12 December 2020

Mapping the collagen-binding site in the von Willebrand factor-A3 domain

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12 December 2020

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

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12 December 2020

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.

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12 December 2020

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

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12 December 2020

The incredible journey: From megakaryocyte development to platelet formation.

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12 December 2020

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

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12 December 2020

WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling

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12 December 2020

Normal Arp2/3 complex activation in platelets lacking WASp.

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12 December 2020

Neuraminidase-induced thrombocytopenia in mice: effects on thrombopoiesis

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12 December 2020

Cytoskeletal regulation of platelet formation: Coordination of F-actin and microtubules

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12 December 2020

Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody

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12 December 2020

Wiskott-Aldrich syndrome protein and platelets

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12 December 2020

Sustained thrombocytopenia in mice: serial studies of megakaryocytes and platelets

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12 December 2020

Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets

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12 December 2020

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways

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12 December 2020

A major role for Scar/WAVE-1 downstream of GPVI in platelets

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12 December 2020

Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth

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12 December 2020

Inflammation induces hemorrhage in thrombocytopenia

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12 December 2020

10.1182/BLOODADVANCES.2017006973

Identifiers

DOI

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8 April 2020

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PubMed publication ID

29104956

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