Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer's Disease (Q89598869)

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scientific article published on 05 February 2020

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English	Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer's Disease	scientific article published on 05 February 2020

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32033363 AND SRC:MED&resulttype=core&format=json

6 April 2020

Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer's Disease (English)

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6 April 2020

cognitive deficit

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Alzheimer's disease

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based on heuristic

inferred from title

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author name string

Sarah Beggiato

1

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6 April 2020

Maria Cristina Tomasini

2

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6 April 2020

Tommaso Cassano

3

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6 April 2020

Luca Ferraro

4

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6 April 2020

publication date

5 February 2020

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6 April 2020

Journal of Clinical Medicine

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6 April 2020

9

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6 April 2020

2

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6 April 2020

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Creative Commons Attribution 4.0 International

5 February 2020

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7074257/fullTextXML

based on heuristic

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

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inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

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Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

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Effect of acylethanolamides on lipid peroxidation and paraoxonase activity.

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LC-MS/MS-ESI method for simultaneous quantitation of three endocannabinoids and its application to rat pharmacokinetic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide protects against the amyloid-β25-35-induced learning and memory impairment in mice, an experimental model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetic resonance spectroscopy in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic mouse models of brain ageing and Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

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inferred from PubMed ID database lookup

CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of anandamide, oleoylethanolamide and palmitoylethanolamide in rodent brain tissue using high performance liquid chromatography-electrospray mass spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between polymorphisms in Interleukin-16 gene and risk of late-onset Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward more predictive genetic mouse models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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PEALut efficacy in mild cognitive impairment: evidence from a SPECT case study!

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

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inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease at 25 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer's Disease Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

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The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Glutamate and NMDA Receptors in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglia, Glutamatergic Transmission and Psychiatric Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: experimental models and reality

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer's Disease: Implications from a Transgenic Mouse Model of the Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte: an innovative approach for Alzheimer's disease therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and astrocytes in Alzheimer's disease: implications for therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial Connexins as a Therapeutic Target for Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide Blunts Amyloid-β42-Induced Astrocyte Activation and Improves Neuronal Survival in Primary Mouse Cortical Astrocyte-Neuron Co-Cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and Neuropsychiatric Disorders in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging of Glial Activation in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox proteomics and amyloid β-peptide: insights into Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo Molecular Imaging of Neuroinflammation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in mouse models of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Palmitoylethanolamide Exerts Antidepressant-Like Effects in Rats: Involvement of PPARα Pathway in the Hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical aspects of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte Function Is Affected by Aging and Not Alzheimer's Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

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based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32033363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/JCM9020428

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Europe PubMed Central

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6 April 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32033363 AND SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32033363 AND SRC:MED&resulttype=core&format=json

6 April 2020

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