Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation (Q89393034)

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4 April 2020

title

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation (English)

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12

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author name string

Jiuli Zhou

1

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4 April 2020

Yongji Zeng

2

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Lian Cui

3

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Xingcheng Chen

4

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Seth Stauffer

5

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Zhan Wang

6

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Fang Yu

7

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Subodh M Lele

8

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Geoffrey A Talmon

9

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Adrian R Black

10

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Yuanhong Chen

11

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publication date

2 July 2018

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Proceedings of the National Academy of Sciences of the United States of America

4 April 2020

published in

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volume

115

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issue

29

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page(s)

E6760-E6769

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describes a project that uses

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ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus

1 reference

12 December 2020

Zyxin: Zinc fingers at sites of cell adhesion

1 reference

12 December 2020

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

12 December 2020

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

1 reference

12 December 2020

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

1 reference

12 December 2020

Elucidation of a universal size-control mechanism in Drosophila and mammals

1 reference

12 December 2020

YAP1 increases organ size and expands undifferentiated progenitor cells

1 reference

12 December 2020

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

1 reference

12 December 2020

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.

1 reference

12 December 2020

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

1 reference

12 December 2020

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

1 reference

12 December 2020

Zyxin emerges as a key player in the mechanotransduction at cell adhesive structures.

1 reference

12 December 2020

The Hippo Signaling Pathway in Development and Cancer

1 reference

12 December 2020

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

1 reference

12 December 2020

KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

1 reference

12 December 2020

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

1 reference

12 December 2020

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

1 reference

12 December 2020

Zyxin Links Fat Signaling to the Hippo Pathway

1 reference

12 December 2020

KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1

1 reference

12 December 2020

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

1 reference

12 December 2020

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.

1 reference

12 December 2020

Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways

1 reference

12 December 2020

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

1 reference

12 December 2020

KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis

1 reference

12 December 2020

CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation

1 reference

12 December 2020

The requirement for cyclin D function in tumor maintenance

1 reference

12 December 2020

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

1 reference

12 December 2020

A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

1 reference

12 December 2020

CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation

1 reference

12 December 2020

Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis

1 reference

12 December 2020

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

1 reference

12 December 2020

Angiomotins link F-actin architecture to Hippo pathway signaling

1 reference

12 December 2020

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

1 reference

12 December 2020

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP

1 reference

12 December 2020

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

1 reference

12 December 2020

Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system

1 reference

12 December 2020

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

1 reference

12 December 2020

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

1 reference

12 December 2020

Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth

1 reference

12 December 2020

Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis

1 reference

12 December 2020

CDK8 kinase--An emerging target in targeted cancer therapy

1 reference

12 December 2020

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors.

1 reference

12 December 2020

Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.

1 reference

12 December 2020

CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

1 reference

12 December 2020

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

1 reference

12 December 2020

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

1 reference

12 December 2020

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

1 reference

12 December 2020

Mechanisms of Hippo pathway regulation

1 reference

12 December 2020

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

1 reference

12 December 2020

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

1 reference

12 December 2020

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

1 reference

12 December 2020

Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

1 reference

12 December 2020

The Hippo pathway in intestinal regeneration and disease

1 reference

12 December 2020

Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis

1 reference

12 December 2020

YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

1 reference

12 December 2020

MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity

1 reference

12 December 2020

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

1 reference

12 December 2020

Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP.

1 reference

12 December 2020

Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.

1 reference

12 December 2020

Intraoperative radiation therapy for colon and rectal cancers: a clinical review

1 reference

12 December 2020

LIM kinases: cofilin and beyond.

1 reference

12 December 2020

Cofilin - a protein controlling dynamics of actin filaments.

1 reference

12 December 2020

Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

1 reference

12 December 2020

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity.

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1800621115

1 reference

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4 April 2020

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PubMed publication ID

29967145

1 reference