Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype (Q89113379)

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scientific article published on 01 June 2018

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English	Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype	scientific article published on 01 June 2018

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31 March 2020

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype (English)

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blood–brain barrier

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Andriy Yabluchanskiy

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Zoltan Ungvari

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Zsuzsanna Tucsek

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Zsuzsanna Tucsek

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William E. Sonntag

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William E Sonntag

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Stefano Tarantini

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M Noa Valcarcel-Ares

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Peter Hertelendy

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Tamas Kiss

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Tripti Gautam

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Xin A Zhang

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31 March 2020

Rafael de Cabo

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Eszter Farkas

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Michael H Elliott

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Michael T Kinter

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Ferenc Deak

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Anna Csiszar

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1 June 2018

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The Journals of Gerontology

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31 March 2020

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31 March 2020

853-863

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31 March 2020

A new planar multielectrode array for extracellular recording: application to hippocampal acute slice

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https://pubmed.ncbi.nlm.nih.gov/29905772

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Reconstitution of gamma-secretase activity

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https://pubmed.ncbi.nlm.nih.gov/29905772

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Assessment of retinal degeneration in outbred albino mice

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https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mid-life adiposity factors relate to blood-brain barrier integrity in late life

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Cognitive impairment following high fat diet consumption is associated with brain inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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NOX activity in brain aging: exacerbation by high fat diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Resveratrol preserves cerebrovascular density and cognitive function in aging mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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A quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

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Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2 signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Rapid stimulus-evoked astrocyte Ca2 elevations and hemodynamic responses in mouse somatosensory cortex in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deleted in Breast Cancer 1 regulates cellular senescence during obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

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High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29905772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1093/GERONA/GLX177

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31 March 2020

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31 March 2020

PubMed publication ID

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29905772 AND SRC:MED&resulttype=core&format=json

31 March 2020

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