Two-step mechanism and step-arrest mutants of Runella slithyformis NAD -dependent tRNA 2'-phosphotransferase Tpt1 (Q89046790)

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30 March 2020

title

Two-step mechanism and step-arrest mutants of Runella slithyformis NAD -dependent tRNA 2'-phosphotransferase Tpt1 (English)

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author name string

Annum Munir

1

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30 March 2020

Leonora Abdullahu

2

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30 March 2020

Masad J Damha

3

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30 March 2020

Stewart Shuman

4

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publication date

8 June 2018

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volume

24

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issue

9

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page(s)

1144-1157

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An enzyme from Saccharomyces cerevisiae uses NAD to transfer the splice junction 2'-phosphate from ligated tRNA to an acceptor molecule

30 March 2020

cites work

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12 December 2020

A highly specific phosphatase from Saccharomyces cerevisiae implicated in tRNA splicing

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12 December 2020

Mechanism of action of a yeast RNA ligase in tRNA splicing

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12 December 2020

An NAD derivative produced during transfer RNA splicing: ADP-ribose 1"-2" cyclic phosphate

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12 December 2020

A 2'-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiae

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12 December 2020

A conditional lethal yeast phosphotransferase (tpt1) mutant accumulates tRNAs with a 2'-phosphate and an undermodified base at the splice junction.

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12 December 2020

A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli

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12 December 2020

Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast

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12 December 2020

The chemical synthesis of oligoribonucleotides with selectively placed 2'-O-phosphates

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12 December 2020

Substrate recognition by a yeast 2'-phosphotransferase involved in tRNA splicing and by its Escherichia coli homolog

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12 December 2020

Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme

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12 December 2020

Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction

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12 December 2020

Genetic and biochemical analysis of the functional domains of yeast tRNA ligase

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12 December 2020

Portability and fidelity of RNA-repair systems

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12 December 2020

Analysis of 2'-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism.

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12 December 2020

Structure-function analysis of the yeast NAD -dependent tRNA 2'-phosphotransferase Tpt1

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12 December 2020

Crystal structure of the RNA 2'-phosphotransferase from Aeropyrum pernix K1

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12 December 2020

An end-healing enzyme from Clostridium thermocellum with 5' kinase, 2',3' phosphatase, and adenylyltransferase activities

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12 December 2020

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

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12 December 2020

Reconstituting bacterial RNA repair and modification in vitro.

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12 December 2020

Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1

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12 December 2020

Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette

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12 December 2020

Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase

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12 December 2020

Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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12 December 2020

Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions

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12 December 2020

Diversity and roles of (t)RNA ligases

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12 December 2020

RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates

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12 December 2020

Mechanism of RNA 2',3'-cyclic phosphate end healing by T4 polynucleotide kinase-phosphatase

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12 December 2020

A kinetic framework for tRNA ligase and enforcement of a 2'-phosphate requirement for ligation highlights the design logic of an RNA repair machine

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12 December 2020

Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase

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12 December 2020

Discrimination of RNA from DNA by polynucleotide phosphorylase

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12 December 2020

Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates

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12 December 2020

Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain

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12 December 2020

Identifiers

DOI

10.1261/RNA.067165.118

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30 March 2020

PubMed publication ID

29884622

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