The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization (Q89018097)

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scientific article published on 06 June 2018

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English	The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization	scientific article published on 06 June 2018

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30 March 2020

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization (English)

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30 March 2020

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30 March 2020

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Mahendravarman Mohanraj

1

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30 March 2020

Ponarulselvam Sekar

2

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30 March 2020

Horng-Huei Liou

3

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30 March 2020

Shwu-Fen Chang

4

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6 June 2018

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30 March 2020

Molecular Neurobiology

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30 March 2020

56

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30 March 2020

2

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30 March 2020

1167-1187

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30 March 2020

Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A constitutive active MEK --> ERK pathway negatively regulates NF-kappa B-dependent gene expression by modulating TATA-binding protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

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High-yield isolation of murine microglia by mild trypsinization.

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https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oregonin inhibits lipopolysaccharide-induced iNOS gene transcription and upregulates HO-1 expression in macrophages and microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intact molecular characterization of cord factor (trehalose 6,6'-dimycolate) from nine species of mycobacteria by MALDI-TOF mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of AMP-activated protein kinase in cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms underlying inflammation in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SYK tyrosine kinase: a crucial player in diverse biological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial cell origin and phenotypes in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-γ1 signaling pathway in murine BV-2 microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPK: a nutrient and energy sensor that maintains energy homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global routine vaccination coverage, 2011.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic vaccination using cationic liposome-adjuvanted HIV type 1 peptides representing HLA-supertype-restricted subdominant T cell epitopes: safety, immunogenicity, and feasibility in Guinea-Bissau

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Bacille Calmette-Guérin after the first demyelinating event in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mincle signaling in the innate immune response after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial and macrophage polarization—new prospects for brain repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-type lectins in immunity: recent developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: multitasking specialists of the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial M1/M2 polarization and metabolic states

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-Mediated Inflammation and Neurodegenerative Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mincle suppresses Toll-like receptor 4 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal Bacillus Calmette-Guérin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An atypical role for the myeloid receptor Mincle in central nervous system injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate effects of P2X7 and extracellular acidification in microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29876879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12035-018-1135-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29876879 AND SRC:MED&resulttype=core&format=json

30 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29876879 AND SRC:MED&resulttype=core&format=json

30 March 2020

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