[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model (Q89014037)

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scientific article published on 07 June 2018

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English	[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model	scientific article published on 07 June 2018

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30 March 2020

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model (English)

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30 March 2020

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30 March 2020

Xavier Decleves

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30 March 2020

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Nicolas Vignal

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30 March 2020

Salvatore Cisternino

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30 March 2020

Nathalie Rizzo-Padoin

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30 March 2020

Fortune Hontonnou

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30 March 2020

Thibaut Gelé

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30 March 2020

Laure Sarda-Mantel

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30 March 2020

Benoît Hosten

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7 June 2018

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30 March 2020

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30 March 2020

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30 March 2020

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30 March 2020

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Creative Commons Attribution 4.0 International

7 June 2018

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Kinetic analysis of L-leucine transport across the blood-brain barrier

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12 December 2020

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

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Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia

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Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways

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12 December 2020

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PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

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12 December 2020

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Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

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12 December 2020

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

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12 December 2020

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PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

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12 December 2020

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Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

1 reference

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12 December 2020

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Microglial physiology: unique stimuli, specialized responses

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12 December 2020

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Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

1 reference

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12 December 2020

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Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Comparison of polarization properties of human adult microglia and blood-derived macrophages

1 reference

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12 December 2020

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Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Positron-emission tomography imaging of the TSPO with [(18)F]FEPPA in a preclinical breast cancer model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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Tau oligomers and fibrils induce activation of microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic modeling without accounting for the vascular component impairs the quantification of [(11)C]PBR28 brain PET data

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging neuroinflammation in gray and white matter in schizophrenia: an in-vivo PET study with [18F]-FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory and cell death pathways in brain and peripheral blood in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune quiescence of the brain is set by astroglial connexin 43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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inferred from PubMed ID database lookup

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Immune attack: the role of inflammation in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

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Systemic inflammation and microglial activation: systematic review of animal experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

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Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography

1 reference

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

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LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoregulation at the gliovascular unit in the healthy brain: A focus on Connexin 43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation in Parkinson's disease using [18F]-FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic modelling of [(11)C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging Microglial Activation in Individuals at Clinical High Risk for Psychosis: an In Vivo PET Study with [18F]FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial Activation in Traumatic Brain Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of endothelial TSPO on the quantification of (18)F-DPA-714.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative diseases: The immunological perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29875332

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Identifiers

10.3390/MOLECULES23061375

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29875332 AND SRC:MED&resulttype=core&format=json

30 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29875332 AND SRC:MED&resulttype=core&format=json

30 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29875332 AND SRC:MED&resulttype=core&format=json

30 March 2020

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