TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31 (Q88960978)

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scientific article published on 01 August 2018

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English	TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31	scientific article published on 01 August 2018

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TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31 (English)

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Huntington's disease

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Michelle L. James

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Michelle L James

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Danielle A Simmons

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Christina Condon

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Adam J Shuhendler

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Zheng Miao

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30 May 2018

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0 references

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

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Increase inω3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumour necrosis factor-α and lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological classification of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

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Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers: beta-CIT, IBF, and iomazenil

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

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12 December 2020

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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-specific localisation of a novel calcium binding protein, Iba1

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graphical analysis of PET data applied to reversible and irreversible tracers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB in neuronal plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early and progressive accumulation of reactive microglia in the Huntington disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

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Visualising microglial activation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

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Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging microglial activation in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of brain-derived neurotrophic factor in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation in presymptomatic Huntington's disease gene carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines, inflammation, and pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator protein 18 kDa is involved in the regulation of reactive gliosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic involvement in Huntington's disease: an in vivo PET study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct neuroinflammatory profile in post-mortem human Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models in neurological disorders: applications of non-invasive imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of 18F- and 11C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of biomarkers for Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Image-derived input function for brain PET studies: many challenges and few opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal peripheral chemokine profile in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of TSPO genotype on 11C-PBR28 standardized uptake values

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the immune system in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninvasive quantification of metabotropic glutamate receptor type 1 with [¹¹C]ITDM: a small-animal PET study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region-Based Partial Volume Correction Techniques for PET Imaging: Sinogram Implementation and Robustness

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington disease: natural history, biomarkers and prospects for therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biomarker development for Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma inflammatory biomarkers for Huntington's disease patients and mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Challenges of Huntington's disease and quest for therapeutic biomarkers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The choreography of neuroinflammation in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methodology of TSPO imaging with positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of PET imaging in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal Fluid Biomarkers for Huntington's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential biomarkers to follow the progression and treatment response of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z-Q175-KI Huntington's disease mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Imaging Markers to Track Huntington’s Disease Pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the effect of fingolimod treatment on microglial activation using serial PET imaging in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial Activation in the Pathogenesis of Huntington's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29860333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDY202

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860333 AND SRC:MED&resulttype=core&format=json

29 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860333 AND SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29860333 AND SRC:MED&resulttype=core&format=json

29 March 2020

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