Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway (Q88763964)

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27 March 2020

title

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway (English)

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author name string

Minji Lee

1

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Jong Hyun Kim

2

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Ina Yoon

3

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Chulho Lee

4

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Mohammad Fallahi Sichani

5

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Jong Soon Kang

6

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Jeonghyun Kang

7

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Min Guo

8

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Kang Young Lee

9

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Gyoonhee Han

10

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Sunghoon Kim

11

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Jung Min Han

12

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publication date

21 May 2018

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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volume

115

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issue

23

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page(s)

E5279-E5288

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Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

27 March 2020

cites work

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12 December 2020

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

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12 December 2020

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

1 reference

12 December 2020

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

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12 December 2020

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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12 December 2020

Regulation of TORC1 by Rag GTPases in nutrient response

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12 December 2020

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

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12 December 2020

A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase

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12 December 2020

Common corruption of the mTOR signaling network in human tumors

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12 December 2020

The mechanism of eukaryotic translation initiation and principles of its regulation

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12 December 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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12 December 2020

mTOR: from growth signal integration to cancer, diabetes and ageing

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12 December 2020

mTOR signaling in disease

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12 December 2020

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

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12 December 2020

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

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12 December 2020

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

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12 December 2020

Regulation of small GTPases by GEFs, GAPs, and GDIs

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12 December 2020

Architecture and metamorphosis

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12 December 2020

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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12 December 2020

Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases

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12 December 2020

Regulation of mTORC1 by amino acids

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12 December 2020

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

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12 December 2020

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

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12 December 2020

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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12 December 2020

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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12 December 2020

Metabolism. Differential regulation of mTORC1 by leucine and glutamine

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12 December 2020

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

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12 December 2020

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

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12 December 2020

Sestrin2 is a leucine sensor for the mTORC1 pathway

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12 December 2020

The mTOR signalling cascade: paving new roads to cure neurological disease

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12 December 2020

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

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12 December 2020

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

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12 December 2020

Nutrient sensing and TOR signaling in yeast and mammals

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12 December 2020

mTOR Signaling in Growth, Metabolism, and Disease.

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12 December 2020

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

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12 December 2020

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.

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12 December 2020

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

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12 December 2020

Structural basis for the assembly of the Ragulator-Rag GTPase complex

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1801287115

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PubMed publication ID

29784813

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