Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing (Q88658178)

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26 March 2020

title

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing (English)

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26 March 2020

2

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Tracey M. Gloster

3

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26 March 2020

David J Vocadlo

7

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26 March 2020

author name string

Tai-Wei Liu

1

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26 March 2020

Lehua Deng

4

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26 March 2020

Kelsey D Murray

5

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26 March 2020

Xiaoyang Shan

6

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26 March 2020

publication date

24 May 2018

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26 March 2020

number of pages

5

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Angewandte Chemie International Edition

inferred from page(s)

published in

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volume

57

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issue

26

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page(s)

7644-7648

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Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

26 March 2020

cites work

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12 December 2020

Effects of the obese gene product on body weight regulation in ob/ob mice

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Weight-reducing effects of the plasma protein encoded by the obese gene

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Positional cloning of the mouse obese gene and its human homologue

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

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12 December 2020

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

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Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

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12 December 2020

A chemical approach for identifying O-GlcNAc-modified proteins in cells

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12 December 2020

Discovery of O-GlcNAc transferase inhibitors

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12 December 2020

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

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12 December 2020

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

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12 December 2020

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

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12 December 2020

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

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12 December 2020

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase

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12 December 2020

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASE

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12 December 2020

Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine

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O-GlcNAc and the cardiovascular system.

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12 December 2020

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition.

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O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat.

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12 December 2020

Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis

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12 December 2020

Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance

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12 December 2020

A small molecule that inhibits OGT activity in cells

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12 December 2020

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains

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12 December 2020

Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria

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12 December 2020

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

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12 December 2020

Protein-Specific Imaging of O-GlcNAcylation in Single Cells.

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12 December 2020

Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression

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12 December 2020

Visualization of Protein-Specific Glycosylation inside Living Cells

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12 December 2020

O-GlcNAc transferase inhibitors: current tools and future challenges.

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12 December 2020

The nutrient sensor OGT in PVN neurons regulates feeding.

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12 December 2020

Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.

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12 December 2020

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

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12 December 2020

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

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12 December 2020

Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells

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12 December 2020

Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation.

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12 December 2020

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

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12 December 2020

Identifiers

DOI

10.1002/ANIE.201803254

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26 March 2020

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26 March 2020

PubMed publication ID

29756380

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