Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder (Q88473811)

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24 March 2020

title

Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29695090 AND SRC:MED&resulttype=core&format=json

major depressive disorder

24 March 2020

main subject

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Wenchao Li

1

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24 March 2020

Jingjian Liu

2

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24 March 2020

Minghua Fan

3

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24 March 2020

Zhongtang Li

4

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24 March 2020

Yin Chen

5

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24 March 2020

Guisen Zhang

6

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24 March 2020

Zhuo Huang

7

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24 March 2020

Liangren Zhang

8

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24 March 2020

publication date

24 April 2018

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24 March 2020

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24 March 2020

volume

23

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24 March 2020

issue

5

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Creative Commons Attribution 4.0 International

24 March 2020

copyright license

start time

24 April 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism

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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

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Inflammatory markers and suicidal attempts in depressed patients: A review

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Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behavior

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12 December 2020

Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions

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Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders.

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BDNF release and signaling are required for the antidepressant actions of GLYX-13.

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12 December 2020

10.3390/MOLECULES23050996

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29695090 AND SRC:MED&resulttype=core&format=json

24 March 2020

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24 March 2020

PubMed publication ID

29695090

1 reference