In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist (Q88160215)

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21 March 2020

title

In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist (English)

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21 March 2020

1

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publication date

24 March 2018

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21 March 2020

published in

Archives of Toxicology

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volume

92

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issue

5

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page(s)

1909-1912

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Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation

21 March 2020

cites work

1 reference

12 December 2020

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

1 reference

12 December 2020

Incidence of drug-induced liver injury in medical inpatients.

1 reference

12 December 2020

Outcome and prognostic markers in severe drug-induced liver disease

1 reference

12 December 2020

Early growth response factor-1 is critical for cholestatic liver injury

1 reference

12 December 2020

Molecular mechanisms of cholestasis.

1 reference

12 December 2020

Mechanisms of cholestasis

1 reference

12 December 2020

1 reference

12 December 2020

New molecular insights into the mechanisms of cholestasis.

1 reference

12 December 2020

Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling

1 reference

12 December 2020

The potential of cytokines as safety biomarkers for drug-induced liver injury

1 reference

12 December 2020

Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells

1 reference

12 December 2020

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

1 reference

12 December 2020

Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease

1 reference

12 December 2020

Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice

1 reference

12 December 2020

The effect of the red wine polyphenol resveratrol on a rat model of biliary obstructed cholestasis: involvement of anti-apoptotic signalling, mitochondrial biogenesis and the induction of autophagy.

1 reference

12 December 2020

Novel insight into mechanisms of cholestatic liver injury

1 reference

12 December 2020

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

1 reference

12 December 2020

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

1 reference

12 December 2020

An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

1 reference

12 December 2020

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

1 reference

12 December 2020

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals

1 reference

12 December 2020

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

1 reference

12 December 2020

The adverse outcome pathway concept: a pragmatic tool in toxicology.

1 reference

12 December 2020

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice

1 reference

12 December 2020

Drug-induced cholestasis

1 reference

12 December 2020

Drug-induced acute liver failure

1 reference

12 December 2020

Suppression of autophagic flux by bile acids in hepatocytes

1 reference

12 December 2020

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

1 reference

12 December 2020

Cholestatic liver disease

1 reference

12 December 2020

The role of canalicular ABC transporters in cholestasis

1 reference

12 December 2020

Atypical causes of cholestasis

1 reference

12 December 2020

Adverse outcome pathway (AOP) development I: strategies and principles

1 reference

12 December 2020

A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.

1 reference

12 December 2020

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

1 reference

12 December 2020

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

1 reference

12 December 2020

Population-representative incidence of drug-induced acute liver failure based on an analysis of an integrated health care system

1 reference

12 December 2020

Activation of autophagy protects against cholestasis-induced hepatic injury

1 reference

12 December 2020

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

1 reference

12 December 2020

Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

1 reference

12 December 2020

A shift in paradigm towards human biology-based systems for cholestatic-liver diseases.

1 reference

12 December 2020

The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways

1 reference

12 December 2020

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

1 reference

12 December 2020

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

1 reference

12 December 2020

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

1 reference

12 December 2020

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

1 reference

12 December 2020

Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity.

1 reference

12 December 2020

Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach

1 reference

12 December 2020

Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

1 reference

12 December 2020

Activation of necroptosis in human and experimental cholestasis.

1 reference

12 December 2020

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

1 reference

12 December 2020

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

1 reference

12 December 2020

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

1 reference

12 December 2020

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

1 reference

12 December 2020

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

1 reference

12 December 2020

Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes

1 reference

12 December 2020

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

1 reference

12 December 2020

The role of Kupffer cells in hepatic diseases

1 reference

12 December 2020

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

1 reference

12 December 2020

Adverse outcome pathways: a concise introduction for toxicologists

1 reference

12 December 2020

Adverse outcome pathways: opportunities, limitations and open questions

1 reference

12 December 2020

10.1007/S00204-018-2201-4

Identifiers

DOI

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21 March 2020

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21 March 2020

PubMed publication ID

29574564

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