Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis (Q85036285)

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14 February 2020

title

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis (English)

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14 February 2020

1

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14 February 2020

Erin Guest

series ordinal

3

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14 February 2020

4

Ali Shilatifard

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14 February 2020

author name string

Chengqi Lin

series ordinal

2

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14 February 2020

publication date

16 September 2010

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14 February 2020

published in

Nature Reviews Cancer

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14 February 2020

volume

10

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14 February 2020

issue

10

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14 February 2020

page(s)

721-728

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An RNA polymerase II elongation factor encoded by the human ELL gene

14 February 2020

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Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression

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Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

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Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

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Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

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The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

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12 December 2020

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