Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation (Q84954565)

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12 February 2020

title

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation (English)

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7

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Anthony G. M. Barrett

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object named as

Anthony G M Barrett

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author name string

Jullien Rey

1

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Haipeng Hu

2

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Fiona Kyle

3

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Chun-Fui Lai

4

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Laki Buluwela

5

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R Charles Coombes

6

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Simak Ali

8

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James P Snyder

9

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publication date

7 September 2012

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volume

7

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issue

11

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page(s)

1909-1914

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Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world

12 February 2020

cites work

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

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Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes

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The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells

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The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion.

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

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Ligand control of coregulator recruitment to nuclear receptors

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Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.

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Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

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Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

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A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

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Rescoring Docking Hit Lists for Model Cavity Sites: Predictions and Experimental Testing

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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

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Structural Dynamics, Intrinsic Disorder, and Allostery in Nuclear Receptors as Transcription Factors

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Induced Fit Simulations on Nuclear Receptors

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7 January 2021

Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably

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Development of a high-throughput screening assay for inhibitors of aggrecan cleavage using luminescent oxygen channeling (AlphaScreen )

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7 January 2021

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

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7 January 2021

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner

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7 January 2021

Identifiers

DOI

10.1002/CMDC.201200307

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22961990 AND SRC:MED&resulttype=core&format=json

12 February 2020

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