Hsp70: Anti-apoptotic and Tumorigenic Protein (Q84904226)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

title

Hsp70: anti-apoptotic and tumorigenic protein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

Hsp70: Anti-apoptotic and Tumorigenic Protein (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-61779-295-3_16

11 December 2024

1 reference

3

Carmen Garrido

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21898238

11 December 2024

author name string

Anne-Laure Rérole

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

Gaëtan Jego

2

1 reference

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12 February 2020

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21898238

11 December 2024

publication date

1 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21898238

full work available at URL

11 December 2024

https://link.springer.com/content/pdf/10.1007/978-1-61779-295-3_16

1 reference

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Methods in Molecular Biology

11 December 2024

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

volume

787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

205-230

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21898238 AND SRC:MED&resulttype=core&format=json

A new puffing pattern induced by temperature shock and DNP in drosophila

12 February 2020

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11 December 2024

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11 December 2024

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11 December 2024

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11 December 2024

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The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.

11 December 2024

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A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro

11 December 2024

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11 December 2024

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11 December 2024

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HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis

11 December 2024

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11 December 2024

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11 December 2024

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11 December 2024

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11 December 2024

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11 December 2024

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11 December 2024

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FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity

11 December 2024

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11 December 2024

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11 December 2024

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Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

11 December 2024

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Heat-shock protein 70 antagonizes apoptosis-inducing factor

11 December 2024

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Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.

11 December 2024

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Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis

11 December 2024

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Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP

11 December 2024

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Caspase-independent cell death in T lymphocytes

11 December 2024

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

11 December 2024

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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

11 December 2024

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Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak

11 December 2024

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11 December 2024

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Lysosomal destabilization in p53-induced apoptosis

11 December 2024

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Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human Fibroblasts

11 December 2024

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

11 December 2024

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Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

11 December 2024

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Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

11 December 2024

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Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

11 December 2024

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Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes

11 December 2024

108

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Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release

11 December 2024

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Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

11 December 2024

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Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

11 December 2024

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Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer

11 December 2024

112

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Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis

11 December 2024

113

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Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia

11 December 2024

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Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy

11 December 2024

116

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Heat shock proteins (HSP70 and HSP27) as markers of epithelial dysplasia in oral leukoplakia.

11 December 2024

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Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma

11 December 2024

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Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells

11 December 2024

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Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

11 December 2024

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Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

11 December 2024

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Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

11 December 2024

123

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Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.

11 December 2024

124

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Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.

11 December 2024

125

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Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.

11 December 2024

126

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Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70

11 December 2024

127

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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

11 December 2024

128

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Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

11 December 2024

129

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A small molecule inhibitor of inducible heat shock protein 70.

11 December 2024

130

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2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

11 December 2024

131

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

11 December 2024

132

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A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

11 December 2024

133

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Chemical manipulation of hsp70 ATPase activity regulates tau stability.

11 December 2024

134

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Mortalin sensitizes human cancer cells to MKT-077-induced senescence

11 December 2024

135

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Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

11 December 2024

136

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Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen

11 December 2024

137

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A novel class of small molecule inhibitors of Hsp90.

11 December 2024

138

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Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip

11 December 2024

139

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Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells

11 December 2024

140

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Geldanamycin inhibits TGF-beta signaling through induction of Hsp70.

11 December 2024

141

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Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

11 December 2024

143

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Journal of Clinical Investigation

11 December 2024

144

120

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HSP70 peptidembearing and peptide-negative preparations act as chaperokines

11 December 2024

145

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Surface expression of Hsp25 and Hsp72 differentially regulates tumor growth and metastasis

11 December 2024

146

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Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.

11 December 2024

147

1 reference

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Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function

11 December 2024

148

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Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability

11 December 2024

149

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Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells

11 December 2024

150

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Mechanisms of HSP72 release.

11 December 2024

151

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Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes

11 December 2024

152

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Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.

11 December 2024

153

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Roles of heat-shock proteins in innate and adaptive immunity

11 December 2024

154

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Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity

11 December 2024

155

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Heat shock protein 70-associated peptides elicit specific cancer immunity

11 December 2024

156

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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

11 December 2024

157

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The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

11 December 2024

158

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Heat shock proteins refine the danger theory

11 December 2024

160

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Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.

11 December 2024

161

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CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

11 December 2024

163

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CD91: a receptor for heat shock protein gp96

11 December 2024

164

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The heat-shock protein receptors: some answers and more questions

11 December 2024

165

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Characterization of a receptor for heat shock protein 70 on macrophages and monocytes

11 December 2024

166

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Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules

11 December 2024

167

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Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8 T cell effector function

11 December 2024

168

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Stress proteins and immunity mediated by cytotoxic T lymphocytes

11 December 2024

169

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Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis

11 December 2024

170

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Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world

11 December 2024

171

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Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view

11 December 2024

172

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High-affinity interactions between peptides and heat shock protein 70 augment CD8 T lymphocyte immune responses

11 December 2024

173

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The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins

11 December 2024

174

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Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

11 December 2024

175

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Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling.

11 December 2024

176

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70-kDa heat shock proteins: specific interactions with HLA-DR molecules and their peptide fragments

11 December 2024

177

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The danger model: a renewed sense of self

11 December 2024

178

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Fusion proteins of Hsp70 with tumor-associated antigen acting as a potent tumor vaccine and the C-terminal peptide-binding domain of Hsp70 being essential in inducing antigen-independent anti-tumor response in vivo

11 December 2024

179

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Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas

11 December 2024

180

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Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages

11 December 2024

181

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GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production

11 December 2024

182

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A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides

11 December 2024

183

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Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study

11 December 2024

184

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Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer

11 December 2024

185

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Induction of leukemia-specific antibodies by immunotherapy with leukemia-cell-derived heat shock protein 70.

11 December 2024

186

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Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma

11 December 2024

187

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Both CD4 and CD8 T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors

11 December 2024

188

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A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis

11 December 2024

189

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Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells.

11 December 2024

190

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A pilot study with a therapeutic vaccine based on hydroxyapatite ceramic particles and self-antigens in cancer patients

11 December 2024

191

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Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination

11 December 2024

192

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Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94.

11 December 2024

193

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Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells

11 December 2024

194

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Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response

11 December 2024

195

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Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells

11 December 2024

196

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Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells

11 December 2024

197

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Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.

11 December 2024

198

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Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.

11 December 2024

199

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11 December 2024

Identifiers

1 reference

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12 February 2020

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