Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats (Q84789545)

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scientific article published on 13 August 2012

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English	Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats	scientific article published on 13 August 2012

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11 February 2020

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats (English)

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11 February 2020

Robert Schierwagen

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11 February 2020

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11 February 2020

Sabine D. Klein

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11 February 2020

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Sebastian Huss

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11 February 2020

Michaela Granzow

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Michaela Granzow

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11 February 2020

Jacob Nattermann

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Jacob Nattermann

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11 February 2020

Tilman Sauerbruch

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Tilman Sauerbruch

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11 February 2020

Christian Körner

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Christian Körner

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11 February 2020

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Jeremias Klösel

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11 February 2020

Irela Gretchen Reza Mazar

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11 February 2020

Susanne Weber

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11 February 2020

Peter F M van den Ven

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11 February 2020

Ursula Pieper-Fürst

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11 February 2020

Dieter O Fürst

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11 February 2020

Frank Lammert

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11 February 2020

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13 August 2012

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11 February 2020

Laboratory Investigation

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11 February 2020

92

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11 February 2020

10

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11 February 2020

1440-1450

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11 February 2020

Mechanisms of hepatic fibrogenesis

1 reference

https://api.crossref.org/works/10.1038/LABINVEST.2012.106

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Mesenchymal cells in the liver--one cell type or two?

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PDGF and signal transduction in hepatic stellate cells

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7 January 2021

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Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets

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7 January 2021

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Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario.

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Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

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Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

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Hepatic fibrosis - therapeutic strategies

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Senescence of activated stellate cells limits liver fibrosis

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7 January 2021

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Senescence: not just for tumor suppression

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Senescence of activated stellate cells: not just early retirement

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Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells

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Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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The essence of senescence

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Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis

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Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells.

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