Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression (Q84702932)

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9 February 2020

title

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression (English)

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author name string

Christian Bogner

1

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Tobias Dechow

2

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Michaela Wagner

4

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Madlen Oelsner

5

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Gloria Lutzny

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Thomas Licht

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Christian Peschel

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Ira Pastan

9

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Robert J Kreitman

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Thomas Decker

11

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publication date

11 October 2009

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British Journal of Haematology

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published in

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volume

148

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issue

1

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page(s)

99-109

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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cites work

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

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The Bcl-2 apoptotic switch in cancer development and therapy

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Quantitative analysis of bcl-2 expression in normal and leukemic human B-cell differentiation

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High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission

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Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies.

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Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: a key in Bak?

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

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Cell death: critical control points

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Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

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Dependence of surface monoclonal antibody binding on dynamic changes in FcgammaRIIb expression

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PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma

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Role of caspases in immunotoxin-induced apoptosis of cancer cells

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Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

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Immunotoxins in cancer therapy

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The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

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A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group

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Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

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Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol

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Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses

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Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement

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Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory foll

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Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival

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Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL).

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World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.

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Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

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Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin.

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Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma

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Biology and management of mantle cell lymphoma

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Cloning and expression of a gene segment encoding the enzymatic moiety of Pseudomonas aeruginosa exotoxin A

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Current treatment standards and future strategies in mantle cell lymphoma

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Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

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Drug resistance in diffuse large B-cell lymphoma

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Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors

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Characterization of a new non-Hodgkin's lymphoma cell line (NCEB-1) with a chromosomal (11:14) translocation [t(11:14)(q13;q32)]

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Prognostic factors for disease progression after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for recurrent or refractory Hodgkin's lymphoma.

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Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

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pEF-BOS, a powerful mammalian expression vector

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Immunotoxin therapy of cancer

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The Hallmarks of Cancer

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies

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12 December 2020

Establishment and characterization of a mantle cell lymphoma cell line

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12 December 2020

Quantitative flow cytometry for the differential diagnosis of leukemic B-cell chronic lymphoproliferative disorders

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12 December 2020

Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels.

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12 December 2020

10.1111/J.1365-2141.2009.07939.X

Identifiers

DOI

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9 February 2020

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