Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys (Q84236369)

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2 February 2020

title

Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys (English)

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2 February 2020

Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys (English)

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3 December 2024

author name string

Jing Pan

6

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2 February 2020

Pericles Calias

9

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Brian R. Felice

1

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3 December 2024

Teresa L. Wright

2

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Robert B. Boyd

3

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Mark T. Butt

4

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Richard W. Pfeifer

5

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Juan A. Ruiz

7

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Michael W. Heartlein

8

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3 December 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21628718

3 December 2024

publication date

31 May 2011

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full work available at URL

2 February 2020

https://journals.sagepub.com/doi/pdf/10.1177/0192623311409595

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https://journals.sagepub.com/doi/pdf/10.1177/0192623311409595

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published in

Toxicologic Pathology

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volume

39

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issue

5

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2 February 2020

page(s)

879-892

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Repeated intrathecal injections of recombinant human 4-sulphatase remove dural storage in mature mucopolysaccharidosis VI cats primed with a short-course tolerisation regimen

2 February 2020

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Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid

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Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II

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Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

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Effect of high dose, repeated intra-cerebrospinal fluid injection of sulphamidase on neuropathology in mucopolysaccharidosis type IIIA mice.

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Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease.

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Effect of cisternal sulfamidase delivery in MPS IIIA Huntaway dogs--a proof of principle study.

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Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF in rhesus monkeys

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Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I

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Enzyme replacement therapy for the mucopolysaccharide storage disorders

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Biochemical and pharmacological characterization of different recombinant acid alpha-glucosidase preparations evaluated for the treatment of Pompe disease

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A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome)

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Intrathecal administration of recombinant human N-acetylgalactosamine 4-sulfatase to a MPS VI patient with pachymeningitis cervicalis.

3 December 2024

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Intrathecal enzyme replacement therapy in a patient with mucopolysaccharidosis type I and symptomatic spinal cord compression

3 December 2024

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Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

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Brain endothelial cell-cell junctions: how to "open" the blood brain barrier

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Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor

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Hunter syndrome presenting as macrocephaly and hydrocephalus

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Delivery, distribution, and neuronal uptake of exogenous mannose-terminal glucocerebrosidase in the intact rat brain

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3 December 2024

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21628718 AND SRC:MED&resulttype=core&format=json

2 February 2020

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