Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo (Q83419379)

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22 January 2020

title

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo (English)

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22 January 2020

author name string

Sridhar Narayan

1

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22 January 2020

Hongsheng Cheng

3

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22 January 2020

Krista Condon

4

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22 January 2020

Hong Du

5

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22 January 2020

Sean Eckley

6

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22 January 2020

Yongbo Hu

7

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22 January 2020

Yimin Jiang

8

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22 January 2020

Vipul Kumar

9

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Philip Saxton

11

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22 January 2020

Edgar Schuck

12

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22 January 2020

Karen Tendyke

14

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22 January 2020

Huiming Zhang

15

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22 January 2020

Wanjun Zheng

16

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22 January 2020

Eric M. Carlson

2

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24 November 2024

Bryan M. Lewis

10

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24 November 2024

Boris M. Seletsky

13

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24 November 2024

Bruce A. Littlefield

17

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24 November 2024

Murray J. Towle

18

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24 November 2024

Melvin J. Yu

19

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24 November 2024

language of work or name

English

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National Center for Biotechnology Information

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24 November 2024

publication date

25 January 2011

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full work available at URL

22 January 2020

https://api.elsevier.com/content/article/PII:S0960894X1100120X?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/J.BMCL.2011.01.097

https://api.elsevier.com/content/article/PII:S0960894X1100120X?httpAccept=text/plain

24 November 2024

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Bioorganic & Medicinal Chemistry Letters

24 November 2024

published in

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22 January 2020

volume

21

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22 January 2020

issue

6

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22 January 2020

page(s)

1634-1638

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Emerging agents in the treatment of anthracycline- and taxane-refractory metastatic breast cancer

22 January 2020

cites work

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Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer

24 November 2024

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Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability

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The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

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Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase

24 November 2024

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Microtubule-binding agents: a dynamic field of cancer therapeutics

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Clinical relevance of P-glycoprotein in drug therapy

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Multidrug resistance through the spectacle of P-glycoprotein.

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The role of ABC transporters in drug resistance, metabolism and toxicity

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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

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Role of P-glycoprotein in drug disposition

24 November 2024

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Preferential efflux by P-glycoprotein, but not MRP1, of compounds containing a free electron donor amine

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P-glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine

24 November 2024

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Macrocyclic ketone analogues of halichondrin B.

24 November 2024

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Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein

24 November 2024

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24 November 2024

Identifiers

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22 January 2020

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