Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia (Q83230375)

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20 January 2020

title

Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia (English)

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20 January 2020

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Tauchi T

1

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20 January 2020

Shin-ya K

2

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20 January 2020

Sashida G

3

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20 January 2020

Sumi M

4

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20 January 2020

Okabe S

5

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20 January 2020

Ohyashiki JH

6

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20 January 2020

Ohyashiki K

7

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20 January 2020

publication date

1 May 2006

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20 January 2020

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20 January 2020

volume

25

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20 January 2020

issue

42

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20 January 2020

page(s)

5719-5725

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PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

20 January 2020

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Telomere maintenance mechanisms as a target for drug development

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Protection of mammalian telomeres

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Interaction of telomestatin with the telomeric single-strand overhang.

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Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

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Senescence Induced by Altered Telomere State, Not Telomere Loss

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Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

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G-quadruplex DNA: a target for drug design

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ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis

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Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy

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p38 MAP kinases: beyond the stress response

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Telomeres and telomerase in hematologic neoplasia

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

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7 January 2021

Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma

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7 January 2021

Inhibition of human telomerase by a G-quadruplex-interactive compound

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7 January 2021

Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

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7 January 2021

Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

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Origin of Concatemeric T7DNA

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Telomerase inhibitors

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7 January 2021

Inhibition of telomerase by G-quartet DNA structures

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