Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas (Q82297408)

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15 January 2020

title

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas (English)

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6

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Murray O. Robinson

15

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12

Tyler Jacks

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author name string

Yinghui Zhou

1

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William M Rideout

2

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Tong Zi

3

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Angela Bressel

4

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Shailaja Reddypalli

5

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Jin-Kyeung Woo

7

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James W Horner

8

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Lynda Chin

9

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M Isabel Chiu

10

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Marcus Bosenberg

11

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Steven C Clark

13

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Ronald A Depinho

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Joerg Heyer

16

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publication date

20 December 2009

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volume

28

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issue

1

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page(s)

71-78

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Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

15 January 2020

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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

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Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

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12 December 2020

Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

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12 December 2020

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

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p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1038/NBT.1595

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15 January 2020

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