Understanding type 1 diabetes through genetics: advances and prospects (Q82065036)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

title

Understanding type 1 diabetes through genetics: advances and prospects (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

Constantin Polychronakos

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

author name string

Quan Li

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

publication date

18 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

781-792

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22005987 AND SRC:MED&resulttype=core&format=json

A genome-wide search for human type 1 diabetes susceptibility genes

14 January 2020

cites work

1 reference

Concordance for islet autoimmunity among monozygotic twins

31 March 2020

1 reference

Secondary attack rate of type 1 diabetes in Colorado families

31 March 2020

1 reference

Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

31 March 2020

1 reference

Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends

31 March 2020

1 reference

The geoepidemiology of type 1 diabetes

31 March 2020

1 reference

Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium

31 March 2020

1 reference

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

31 March 2020

1 reference

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

31 March 2020

1 reference

Remapping the insulin gene/IDDM2 locus in type 1 diabetes

31 March 2020

1 reference

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

31 March 2020

1 reference

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

31 March 2020

1 reference

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

31 March 2020

1 reference

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

1 reference

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

31 March 2020

1 reference

Toward further mapping of the association between the IL2RA locus and type 1 diabetes

31 March 2020

1 reference

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

31 March 2020

1 reference

Detecting shared pathogenesis from the shared genetics of immune-related diseases

31 March 2020

1 reference

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

31 March 2020

1 reference

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

31 March 2020

1 reference

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

31 March 2020

1 reference

Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes

31 March 2020

1 reference

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

31 March 2020

1 reference

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci

31 March 2020

1 reference

Finding the missing heritability of complex diseases

31 March 2020

1 reference

Promise and pitfalls of the Immunochip

31 March 2020

1 reference

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.

31 March 2020

1 reference

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

31 March 2020

1 reference

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

31 March 2020

1 reference

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

31 March 2020

1 reference

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

31 March 2020

1 reference

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes

31 March 2020

1 reference

Common regulatory variation impacts gene expression in a cell type-dependent manner

31 March 2020

1 reference

A genome-wide association study of global gene expression

31 March 2020

1 reference

Genetics of type 1A (immune mediated) diabetes

31 March 2020

1 reference

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families

31 March 2020

1 reference

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

31 March 2020

1 reference

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

31 March 2020

1 reference

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity

31 March 2020

1 reference

Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line

31 March 2020

1 reference

Simultaneous detection of circulating autoreactive CD8 T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

31 March 2020

1 reference

Imprinted and Genotype-specific Expression of Genes at theIDDM2Locus in Pancreas and Leucocytes

31 March 2020

1 reference

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

31 March 2020

1 reference

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

31 March 2020

1 reference

A central role for central tolerance

31 March 2020

1 reference

Projection of an immunological self shadow within the thymus by the aire protein

31 March 2020

1 reference

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

31 March 2020

1 reference

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

31 March 2020

1 reference

Tolerance to proinsulin-2 is due to radioresistant thymic cells

31 March 2020

1 reference

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

31 March 2020

1 reference

Thymus-specific deletion of insulin induces autoimmune diabetes

31 March 2020

1 reference

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes

31 March 2020

1 reference

Lymphotoxin pathway directs thymic Aire expression

31 March 2020

1 reference

Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells.

31 March 2020

1 reference

Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.

31 March 2020

1 reference

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

31 March 2020

1 reference

Sequence Requirements for Association of Protein-tyrosine Phosphatase PEP with the Src Homology 3 Domain of Inhibitory Tyrosine Protein Kinase p50

31 March 2020

1 reference

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

31 March 2020

1 reference

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

31 March 2020

1 reference

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

31 March 2020

1 reference

Regulatory T Cells: History and Perspective

31 March 2020

1 reference

The type I diabetes association of the IL2RA locus.

31 March 2020

1 reference

A cis-Acting Regulatory Variant in the IL2RA Locus

31 March 2020

1 reference

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

31 March 2020

1 reference

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

31 March 2020

1 reference

A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele

31 March 2020

1 reference

Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' 6230G>A polymorphism

31 March 2020

1 reference

Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

31 March 2020

1 reference

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo

31 March 2020

1 reference

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

31 March 2020

1 reference

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3

31 March 2020

1 reference

Increased incidence and prevalence of diabetes mellitus in Down's syndrome

31 March 2020

1 reference

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

31 March 2020

1 reference

Study of transcriptional effects in Cis at the IFIH1 locus

31 March 2020

1 reference

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

31 March 2020

1 reference

Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients

31 March 2020

1 reference

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

31 March 2020

1 reference

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

31 March 2020

1 reference

Mapping the genetic architecture of gene expression in human liver

31 March 2020

1 reference

Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13.

31 March 2020

1 reference

Prediction and interaction in complex disease genetics: experience in type 1 diabetes

31 March 2020

1 reference

Hypermutable non-synonymous sites are under stronger negative selection

31 March 2020

1 reference

Genome structural variation discovery and genotyping

31 March 2020

1 reference

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

31 March 2020

1 reference

What can exome sequencing do for you?

31 March 2020

1 reference

Lessons on autoimmune diabetes from animal models

31 March 2020

1 reference

Use of nonobese diabetic mice to understand human type 1 diabetes

31 March 2020

1 reference

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

31 March 2020

1 reference

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene

31 March 2020

1 reference

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

31 March 2020

1 reference

12 December 2020

Genetic analysis of the hypervariable region flanking the human insulin gene.

1 reference

12 December 2020

Assessing the role of HLA-linked and unlinked determinants of disease

1 reference

12 December 2020

Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes Epidemiology Research International Group

1 reference

12 December 2020

Autoimmune insulitis. Pathological findings in experimental animal models and juvenile diabetes mellitus

1 reference

12 December 2020

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

1 reference

12 December 2020